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Rupatadine

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Identification
Molecular formula
C26H26ClN3
CAS number
158876-82-5
IUPAC name
5-methyl-2-(1-methyl-4-piperidylidene)-4,6-diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene
State
State

At room temperature, rupatadine is in a solid state. It is commonly found as a powder which can be pressed into tablets for pharmacological use.

Melting point (Celsius)
123.50
Melting point (Kelvin)
396.65
Boiling point (Celsius)
224.00
Boiling point (Kelvin)
497.15
General information
Molecular weight
415.96g/mol
Molar mass
8.7900g/mol
Density
1.2200g/cm3
Appearence

Rupatadine is typically found as a crystalline powder that is white to off-white in color. It is almost odorless and generally hygroscopic in nature.

Comment on solubility

Solubility of 5-methyl-2-(1-methyl-4-piperidylidene)-4,6-diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene

The solubility of 5-methyl-2-(1-methyl-4-piperidylidene)-4,6-diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene in various solvents is a critical aspect to understand for its applications. Here are some key points regarding its solubility:

  • Polar Solvents: This compound tends to have limited solubility in polar solvents, such as water, due to its complex structure and potential hydrophobic regions that inhibit interactions with water molecules.
  • Non-Polar Solvents: Solubility is often more favorable in non-polar solvents like benzene or chloroform, where the compound can better align its electronic structure with that of the solvent.
  • Temperature Effects: Increasing the temperature might enhance solubility in some solvents, facilitating better molecular interactions.
  • Miscibility Considerations: It's important to note that due to its unique piperidine-like structure, the miscibility with other pharmaceutical-grade solvents can vary significantly based on the conditions.

In conclusion, the solubility behavior of this compound is influenced by its structural characteristics and the nature of the solvent employed. Understanding these factors can aid in the practical applications of 5-methyl-2-(1-methyl-4-piperidylidene)-4,6-diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene in chemical formulations and processes.

Interesting facts

Interesting Facts about 5-Methyl-2-(1-Methyl-4-piperidylidene)-4,6-Diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene

This fascinating compound belongs to the class of organic molecules known for their complex structures and significant biological activities. Here are some captivating insights:

  • Cyclic Structures: The presence of a diazatricyclo structure suggests an intricate arrangement of atoms that may exhibit unique chemical properties due to ring strain and steric hindrance.
  • Biological Relevance: Compounds similar to this one often display interesting pharmaceutical properties, making them potential candidates for drug development. Their complex nitrogen-rich framework opens avenues for targeting specific biological mechanisms.
  • Potential Applications: Research indicates that such compounds may exhibit anti-inflammatory, analgesic, or even anti-cancer properties. This highlights the importance of understanding the structure-activity relationship in medicinal chemistry.
  • Synthesis Challenges: The synthesis of such complex structures can be challenging, often requiring advanced techniques in organic synthesis, including multi-step reactions and careful control of reaction conditions.
  • The Role of Substituents: The presence of functional groups like the piperidine ring in this compound can significantly influence its reactivity and biological activity, making it a point of study in understanding organic reaction mechanisms.

In summary, the compound 5-methyl-2-(1-methyl-4-piperidylidene)-4,6-diazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaene represents a blend of complexity and potential, illustrating the wonderful intricacies of organic chemistry.