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Alprazolam

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Identification
Molecular formula
C17H13ClF3N3
CAS number
28981-97-7
IUPAC name
5-methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one
State
State

At room temperature, alprazolam exists as a solid. It is used in pharmaceutical formulations primarily in tablet form for medicinal use.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
708.20
Boiling point (Kelvin)
981.35
General information
Molecular weight
308.77g/mol
Molar mass
308.7690g/mol
Density
1.5000g/cm3
Appearence

Alprazolam appears as a white crystalline powder, which is practically odorless. It typically has a bitter taste.

Comment on solubility

Solubility of 5-methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one

The solubility of 5-methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one can be quite complex, as it depends on various factors such as polarity, molecular size, and intermolecular interactions. In general, this compound is expected to exhibit the following characteristics:

  • Polar vs. Non-Polar: The presence of the trifluoromethyl (CF3) group may increase the non-polar characteristics of the molecule, potentially reducing its solubility in polar solvents like water.
  • Solvent Compatibility: It is likely to show better solubility in organic solvents such as dichloromethane, ethanol, or dimethyl sulfoxide (DMSO).
  • Temperature Dependency: Solubility can also be temperature-dependent, with higher temperatures possibly enhancing solubility in chosen solvents.

In summary, while detailed solubility data may not be readily available for this specific compound, it is crucial to experiment with various solvents and conditions to ascertain its solubility behavior accurately. As with many chemical compounds, the context of its use and environment significantly influences solubility.

Interesting facts

Interesting Facts about 5-Methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one

This fascinating compound belongs to the class of benzodiazepines, which are widely recognized for their role in pharmacology and medicinal chemistry. Here are some intriguing points about it:

  • Unique Structure: The molecular structure includes a trifluoromethyl group, which is known to enhance biological activity and contributes to the compound's lipophilicity.
  • Applications: Compounds like this one often serve as important leads in drug development, particularly in treating anxiety disorders, insomnia, and other conditions related to the central nervous system.
  • Importance of Methyl Substitution: The presence of a methyl group in its structure can play a crucial role in determining the pharmacokinetics and pharmacodynamics of the compound, influencing how it behaves in biological systems.
  • Complexity of Synthesis: The synthesis of such complex molecules often involves multiple steps and requires advanced techniques in organic chemistry, making it a notable subject for students and researchers alike.
  • Potential Research Avenues: Ongoing studies of similar compounds may lead to the discovery of new therapeutic agents that could provide improved efficacy and safety profiles.

In conclusion, 5-methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one exemplifies the intricate relationship between chemical structure and biological activity. Its multifaceted nature invites further exploration into its potential applications in medicine and chemistry.

Synonyms
10243-44-4
BRN 0766956
5-Methyl-6,7,9,10-tetrahydro-2-trifluoromethyl-5H-isoquino(2,1-d)(1,4)benzodiazepin-6-one
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-5-methyl-2-(trifluoromethyl)-
5-methyl-2-(trifluoromethyl)-7,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6-one
5,9,10,14b-Tetrahydro-5-methyl-2-(trifluoromethyl)isoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
DTXSID60907506
5-Methyl-2-(trifluoromethyl)-5,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6(7H)-one