5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

Identification

Molecular formula

C₁₅H₁₈N₂

CAS number

221618-46-8

IUPAC name

5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

State

At room temperature, this compound is a solid. It remains stable under normal conditions and should be stored in a cool, dry place.

Melting point (Celsius)

138.00

Melting point (Kelvin)

411.15

Boiling point (Celsius)

425.00

Boiling point (Kelvin)

698.15

General information

Molecular weight

226.32g/mol

Molar mass

226.3190g/mol

Density

1.2300g/cm³

Appearence

The compound is generally a white to off-white crystalline powder. The crystals may have a shiny appearance and are typically formed in irregular shapes.

Comment on solubility

Solubility of 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

The solubility of 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole in various solvents and conditions is an important aspect to consider when studying its properties and applications. This compound, being relatively complex, exhibits a range of solubility behaviors:

Polar solvents: Generally, compounds with nitrogen-containing functional groups, such as those present in this molecule, tend to have increased solubility in polar solvents, including water and alcohols.
Nonpolar solvents: While 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole may show limited solubility in nonpolar solvents, the hydrophobic character of the indole ring can enhance its solubility in organic solvents such as dichloromethane or hexane.
Temperature effects: The solubility is often temperature-dependent, with many organic compounds becoming more soluble at higher temperatures.

In conclusion, solubility plays a critical role in the utilization of 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole across different applications, particularly in pharmaceutical and chemical processes. Understanding its solubility profile allows for better optimization during synthesis and application.

Interesting facts

Interesting Facts about 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole is a fascinating compound, especially noted for its molecular structure which incorporates both indole and pyrrolidine moieties. This unique combination leads to several interesting implications and research avenues:

Biological Importance: Compounds containing indole structures are frequently studied for their biological activities. They can exhibit diverse pharmacological effects including antidepressant and anti-inflammatory properties.
Drug Development: The 1H-indole core is a crucial component in many pharmaceutical discoveries. Researchers are investigating its potential as a scaffold for designing new therapeutic agents.
Chemical Versatility: The presence of the methylpyrrolidine group enhances the compound's reactivity, making it a versatile intermediate in organic synthesis.
Research Implications: Studies have shown that pyrrolidine derivatives can influence key biochemical pathways, making such compounds of significant interest in the fields of medicinal chemistry and drug design.

Additionally, this compound can be viewed under the lens of structure-activity relationship (SAR) studies. The modifications in the indole structure can lead to profound changes in the biological profile of related compounds, highlighting the importance of even slight structural variations in chemical synthesis and pharmaceutical research.

"Understanding molecular interactions at the level of fine structure is key to unlocking the mysteries of drug action." This quote resonates with the significance of studying compounds like 5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole, as they may hold the key to new therapeutic strategies.

Synonyms

5-methyl-3-(1-methylpyrrolidin-2-yl)-1H-indole

19137-69-0

5-Methyl-3-(1-methyl-2-pyrrolidinyl)-1H-indole

BRN 0520995

5-Methyl-3-(1-methyl-2-pyrrolidinyl)indole

INDOLE, 5-METHYL-3-(1-METHYL-2-PYRROLIDINYL)-

DTXSID70940742