Skip to main content

5-Methyl-3-phenylisoxazole-4-carboxylic acid

ADVERTISEMENT
Identification
Molecular formula
C11H9NO3
CAS number
702-58-3
IUPAC name
5-methyl-3-phenyl-isoxazole-4-carboxylic acid
State
State

At room temperature, 5-Methyl-3-phenylisoxazole-4-carboxylic acid is in a solid state.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
217.20g/mol
Molar mass
217.2150g/mol
Density
1.3200g/cm3
Appearence

5-Methyl-3-phenylisoxazole-4-carboxylic acid typically appears as a crystalline solid. The compound is generally white to off-white in color.

Comment on solubility

Solubility of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid

The solubility of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid is influenced by its molecular structure and functional groups. This compound's ability to dissolve in various solvents is primarily determined by:

  • Polarity: The presence of the -COOH (carboxylic acid) group contributes to the polarity of the molecule, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The -COOH group can participate in hydrogen bonding, which allows it to interact favorably with water molecules.
  • Non-polar Interactions: The phenyl group introduces non-polar characteristics, which may limit solubility in highly polar solvents but can enhance solubility in non-polar solvents.

In general, it can be stated that:

  • "Like dissolves like" - polar compounds are more soluble in polar solvents, while non-polar compounds are more compatible with non-polar solvents.
  • The solubility of this compound tends to be greater in organic solvents such as ethanol or acetone than in purely aqueous environments.

Due to the balance of its polar and non-polar characteristics, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid exhibits interesting solubility properties that can be harnessed in various applications in chemical synthesis and pharmaceutical formulations.

Interesting facts

Interesting Facts about 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid

5-Methyl-3-phenyl-isoxazole-4-carboxylic acid, often referred to by its abbreviated form, showcases a fascinating interplay of organic chemistry and pharmaceutical applications. This compound belongs to the isoxazole family, characterized by its unique five-membered ring structure that includes both nitrogen and oxygen atoms, making it a heterocyclic compound. Below are some intriguing aspects of this compound:

  • Pharmacological Importance: Compounds in the isoxazole class are notable for their medicinal properties, including anti-inflammatory and analgesic effects. Research indicates that derivatives of isoxazole can exhibit significant bioactivity.
  • Organic Synthesis: 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid can be synthesized through several organic reactions, including cyclization processes. Its synthesis often involves a multi-step reaction, which is a point of interest for many organic chemists.
  • Substituent Effects: The presence of a methyl group at the 5-position and a phenyl group at the 3-position introduces unique electronic and steric properties, impacting the compound's reactivity and interactions with biological targets.
  • Environmental Applications: In some studies, isoxazole derivatives have been highlighted for their potential use in agrochemicals, showcasing their versatility beyond pharmaceuticals.
  • Cultural Footprint: The study of isoxazole compounds has led to innovative research directions, influencing the development of new drugs and materials, thus impacting both the scientific community and commercial industries.

The versatility of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid exemplifies the dynamic field of chemistry. As scientists delve deeper into its properties, the potential for new discoveries and applications continues to expand.

Synonyms
5-Methyl-3-phenylisoxazole-4-carboxylic acid
4-Isoxazolecarboxylic acid, 5-methyl-3-phenyl-
5-Methyl-3-phenyl-4-isoxazolecarboxylic acid
Pmic acid
3-Phenyl-5-methylisoxazol-4-carbonsaeure
3-Phenyl-5-methylisoxazole-4-carboxylic acid
ZL8HD4RP5B
EINECS 214-497-9
NSC 76870
ISOXAZOLE-4-CARBOXYLIC ACID, 5-METHYL-3-PHENYL-
BRN 0164939
UNII-ZL8HD4RP5B
NSC-76870
3-Phenyl-5-methylisoxazol-4-carbonsaeure [German]
DTXSID3061556
4-27-00-04087 (Beilstein Handbook Reference)
OXACILLIN SODIUM MONOHYDRATE IMPURITY C [EP IMPURITY]
OXACILLIN SODIUM MONOHYDRATE IMPURITY C (EP IMPURITY)
DTXCID5033331
214-497-9
penhktnqujmhir-uhfffaoysa-n
1136-45-4
5-methyl-3-phenyl-1,2-oxazole-4-carboxylic acid
5-Methyl-3-phenyl-isoxazole-4-carboxylic acid
5-methyl-3-phenylisoxazole-4-carboxylicacid
5-Methyl-3-phenylisoxazole-4-carboxylic acid; Oxacillin Related Compound C; Oxacillin Sodium Monohydrate Impurity C; Oxacillin Impurity C
MOK
NSC76870
MFCD00003153
Cambridge id 5229752
5-METHYL-3-PHENYLISOXAZOLE-4-CARBOXYLIC
CBDivE_008536
SCHEMBL316093
3-Phenyl-5-methylisoxazol-4-carbonsaeure [German]
WLN: T5NOJ C1 DVQ ER
HMS1631N05
HMS3447E18
BBL005244
STK177355
AKOS000120854
8P-396S
CCG-142813
SDCCGMLS-0065903.P001
5-methyl-3-phenyl-4-isoxazolecarboxylicacid
DB-041181
5-methyl-3-phenylisoxazole-4-carboxlic acid
CS-0005891
NS00023693
UPCMLD00X1136-45-4:001
UPCMLD00X1136-45-4:002
3-phenyl-5-methyl-4-isoxazolecarboxylic acid
5-Methyl-3-phenylisooxazole-4-carboxylic acid
EN300-20783
AQ-360/40723605
5-Methyl-3-phenylisoxazole-4-carboxylic acid, 99%
Q27463383
Z104482458