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2-Amino-5-methylpyridine

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Identification
Molecular formula
C6H8N2
CAS number
1603-40-3
IUPAC name
5-methylpyridin-2-amine
State
State

The compound is typically in a liquid state at room temperature, which is somewhat unusual for aminopyridines, many of which are solids.

Melting point (Celsius)
17.70
Melting point (Kelvin)
290.85
Boiling point (Celsius)
216.00
Boiling point (Kelvin)
489.15
General information
Molecular weight
108.15g/mol
Molar mass
108.1460g/mol
Density
1.0130g/cm3
Appearence

2-Amino-5-methylpyridine typically appears as a colorless to pale yellow liquid. The color may vary slightly between samples due to impurities or decomposition, especially upon exposure to air and light.

Comment on solubility

Solubility of 5-methylpyridin-2-amine

5-methylpyridin-2-amine, with the chemical formula C7H10N2, is a compound that exhibits intriguing solubility properties. Its solubility can be influenced by several factors, including:

  • Polarity: The presence of the amine group (-NH2) increases the polarity of this compound, making it more soluble in polar solvents.
  • Temperature: As with many organic compounds, solubility tends to increase with temperature. Higher temperatures can help dissolve 5-methylpyridin-2-amine in water and other solvents.
  • pH Levels: The solubility can also be affected by the pH of the solution. In basic conditions, the amine group can become protonated, enhancing its solubility in aqueous environments.

In general, 5-methylpyridin-2-amine demonstrates moderate solubility in water, making it suitable for various chemical reactions and applications. However, it is significantly more soluble in organic solvents such as ethanol and methanol due to its hydrophobic alkyl group.

Ultimately, understanding the solubility of this compound is essential for practical applications in synthesis and analysis. As with many nitrogen-containing heterocycles, its unique properties allow it to participate in a variety of important chemical processes.

Interesting facts

Interesting Facts about 5-Methylpyridin-2-amine

5-Methylpyridin-2-amine, often recognized by its role as a versatile building block in organic synthesis, is an intriguing compound with a range of applications. Here are some noteworthy points about this chemical:

  • Structural Significance: The compound consists of a pyridine ring substituted with both a methyl group and an amino group. This specific arrangement not only influences its chemical behavior but also enhances its reactivity.
  • Pharmaceutical Relevance: Compounds similar to 5-methylpyridin-2-amine have been explored for their potential use in drug development, particularly in creating bioactive molecules.
  • Synthesis Versatility: 5-Methylpyridin-2-amine can be synthesized using various methods, making it an interesting subject of study for chemists aiming to optimize reaction pathways.
  • Functional Group Influence: The presence of the amino group significantly increases the compound's potential for forming hydrogen bonds, which can affect solubility and interaction with biological targets.
  • Applications in Material Science: Researchers are investigating the use of 5-methylpyridin-2-amine in the development of new materials, particularly those that require high thermal stability and chemical resilience.

In conclusion, 5-methylpyridin-2-amine is more than just a simple organic compound; it serves as a vital contributor to various fields, especially in medicinal chemistry and materials science. As stated by chemist Joseph Priestley: "The greatest discoveries in science are often made by the people who are not afraid of failure." Understanding the unique properties of compounds like this one can pave the way for significant advancements in our scientific endeavors.

Synonyms
2-Amino-5-methylpyridine
1603-41-4
6-Amino-3-picoline
2-AMINO-5-PICOLINE
2-Pyridinamine, 5-methyl-
6-Amino-3-methylpyridine
5-Methyl-2-aminopyridine
3-Picoline, 6-amino-
5-Methyl-2-pyridinamine
5-Methyl-2-pyridylamine
NSC 1489
NSC 96444
EINECS 216-503-5
BRN 0107050
8UM54T43WT
DTXSID4029220
AI3-52276
NSC-1489
NSC-96444
DTXCID909220
5-22-09-00289 (Beilstein Handbook Reference)
AMINO-3-METHYLPYRIDINE, 6-
inchi=1/c6h8n2/c1-5-2-3-6(7)8-4-5/h2-4h,1h3,(h2,7,8
5-METHYLPYRIDIN-2-AMINE
5-methylpyridin-2-ylamine
2-amino-5-methyl pyridine
5-Methyl-pyridin-2-ylamine
MFCD00006328
(5-Methylpyridin-2-yl)amine
CHEMBL61990
pyridine, 2-amino-5-methyl-
LG4
UNII-8UM54T43WT
amino-5-picoline
6-amino-3 picoline
2-amino-5methylpyridine
5-methyl-2-aminopyridin
5-methylpyridine-2-amine
2-amino-5-methyl-pyridine
2-Amino-5-methylpyridine (2-Amino-5-picoline)
NCIOpen2_001614
SCHEMBL16868
Pyridine, 2-amino-5-methyl
5-methyl-pyridin-2-yl-amine
SCHEMBL10057634
NSC1489
2-Amino-5-methylpyridine, 99%
BCP16835
CS-D0808
NSC96444
STR01239
Tox21_200474
BDBM50091808
RB8006
STK398101
AKOS000119512
AC-4664
FA00539
PS-9284
SDCCGMLS-0066227.P001
NCGC00248645-01
NCGC00258028-01
BP-10235
CAS-1603-41-4
DB-023762
A0732
NS00025220
EN300-19786
2-Amino-5-methylpyridine;5-Methylpyridin-2-amine
AC-907/25014132
Q27271041
F0001-0574
Z104475374