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Furazolidone

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Identification
Molecular formula
C8H7N3O5S
CAS number
67-45-8
IUPAC name
5-(methylsulfanylmethyl)-3-[(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one
State
State

Furazolidone is typically found in a solid state at room temperature. It is slightly soluble in water and has limited stability and solubility in various solvents, which should be considered in its handling and storage.

Melting point (Celsius)
256.00
Melting point (Kelvin)
529.15
Boiling point (Celsius)
432.00
Boiling point (Kelvin)
705.15
General information
Molecular weight
225.22g/mol
Molar mass
225.1990g/mol
Density
1.4280g/cm3
Appearence

Furazolidone appears as a yellow, crystalline powder. It has a characteristic odor and a bitter taste. This compound is typically used in veterinary medicine and as an antimicrobial agent.

Comment on solubility

Solubility of 5-(Methylsulfanylmethyl)-3-[(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one

The solubility of 5-(methylsulfanylmethyl)-3-[(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one can be influenced by various factors including its molecular structure, polarity, and the presence of functional groups. Here are some key points to consider:

  • Polarity: This compound contains both polar and non-polar regions, which suggests it may exhibit variable solubility in different solvents.
  • Functional Groups: The presence of a methylsulfanyl group and a nitro group can enhance the compound's interaction with solvents, potentially improving solubility in polar solvents.
  • Hydrogen Bonding: If the molecule can participate in hydrogen bonding due to its functional groups, this may increase its solubility in protic solvents, such as water and alcohols.
  • General Solubility Guidelines: As a general rule, compounds that are polar tend to dissolve well in polar solvents, while non-polar compounds prefer non-polar solvents. Understanding this can aid in predicting solubility behavior.

In conclusion, to accurately assess the solubility of this compound, empirical testing in various solvents is essential. Working with both polar and non-polar solvents will provide insights into its solubility profile.

Interesting facts

Interesting Facts about 5-(methylsulfanylmethyl)-3-[(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one

This intriguing compound, known for its diverse applications in medicinal chemistry, combines both aromatic and heterocyclic structures, leading to enhanced biological activity. Let's delve into some fascinating aspects of this compound:

  • Pharmaceutical Relevance: The oxazolidinone structure is key to a class of antibacterial agents known as oxazolidinones, which are effective against various Gram-positive bacterial infections.
  • Mechanism of Action: The mechanism typically involves inhibition of bacterial protein synthesis, thereby preventing the growth of bacteria. This highlights its importance in combating antibiotic resistance.
  • Bioisosterism: The incorporation of the furan ring (5-nitro-2-furyl) makes this compound interesting for drug design, as such changes can enhance drug efficacy and reduce side effects.
  • Potential Applications: Beyond antibiotic properties, structural modifications may lead to potential applications in cancer therapy and anti-inflammatory treatments.
  • Research Opportunities: The synthetic pathways to create this compound can lead to exciting research avenues, focusing on novel synthesis techniques or exploring the effects of various substituents on biological activity.

In summary, 5-(methylsulfanylmethyl)-3-[(5-nitro-2-furyl)methyleneamino]oxazolidin-2-one encapsulates a wealth of chemical complexity and therapeutic potential. As scientific advancements continue, the exploration of this compound and its derivatives could yield significant contributions to both medicinal chemistry and pharmacology.

Synonyms
MFCD00057257
DTXSID60863471
SY068782
DB-051625
N1167