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5-Nitroindole

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Identification
Molecular formula
C8H6N2O2
CAS number
614-25-3
IUPAC name
5-nitro-1H-indole
State
State

At room temperature, 5-Nitroindole is typically in a solid state. The compound is commonly found in the form of crystalline powder, presenting as yellow due to the presence of the nitro group.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
319.00
Boiling point (Kelvin)
592.15
General information
Molecular weight
162.15g/mol
Molar mass
162.1460g/mol
Density
1.4081g/cm3
Appearence

5-Nitroindole is a yellow crystalline solid. Its crystalline form is quite distinct due to the bright yellow coloration, which is typical of nitroaromatic compounds. The crystals can vary in size and shape but are generally well-formed.

Comment on solubility

Solubility of 5-nitro-1H-indole

5-nitro-1H-indole, notable for its unique structural features, exhibits interesting solubility characteristics that are noteworthy for researchers and chemists alike. Understanding its behavior in various solvents is essential for its practical applications.


Solubility Characteristics:

  • Solvent Interaction: 5-nitro-1H-indole is generally soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol. Its solubility in polar solvents can be attributed to the presence of the nitro group, which enhances its interaction with solvent molecules.
  • Low Solubility in Water: The compound is poorly soluble in water, which can limit its use in aqueous environments without appropriate modifications.
  • Pure Form Considerations: When handling the pure compound, care must be taken to ensure that it is fully dissolved in the chosen solvent, as impurities can affect solubility

In summary, while 5-nitro-1H-indole displays notable solubility in various organic solvents, its limited aqueous solubility should be taken into consideration for applications that require water-based systems. As always, exploring the “solvent effects” is key when working with this compound, as different solvents can dramatically alter the solubility characteristics.

Interesting facts

Interesting Facts about 5-Nitro-1H-Indole

5-Nitro-1H-indole is a fascinating chemical compound that plays a significant role in various fields, particularly in medicinal chemistry and organic synthesis. Here are some intriguing aspects of this compound:

  • Structural Significance: The presence of both the indole ring system and a nitro group makes 5-nitro-1H-indole a unique compound. The indole structure is essential in many biological processes and is commonly found in many natural products.
  • Biological Activities: Compounds containing the indole motif often exhibit a variety of biological activities. 5-Nitro-1H-indole specifically has been studied for its potential as an anti-cancer agent and has shown promising results in inhibiting the growth of certain tumor cells.
  • Synthetic Pathways: The synthesis of 5-nitro-1H-indole can be achieved through various methods, which often involve the nitration of indole derivatives. This process provides an excellent opportunity for organic chemists to explore different reaction conditions and mechanisms.
  • Fluorescent Properties: Recent studies have indicated that 5-nitro-1H-indole exhibits interesting fluorescent properties, making it a valuable compound for applications in fluorescence microscopy and imaging techniques in biological research.
  • Versatility: The nitro group in the compound can undergo several reactions, expanding its versatility in further synthetic transformations. This makes it a useful intermediate in the development of new pharmaceutical agents.

In conclusion, 5-nitro-1H-indole is not just a simple compound but a vibrant participant in the landscape of chemical research. Its structural features and potential applications offer exciting possibilities for scientists and researchers alike.

Synonyms
5-Nitroindole
6146-52-7
5-Nitro-1H-indole
1H-Indole, 5-nitro-
INDOLE, 5-NITRO-
CCRIS 3255
O2BHX6EDBN
UNII-O2BHX6EDBN
EINECS 228-153-0
NITROINDOLE, 5-
NSC-520594
DTXSID80210403
NSC 520594
5Nitro1Hindole
Indole, 5nitro
1HIndole, 5nitro
1HIndole, 5nitro (9CI)
1H-Indole, 5-nitro-(9CI)
DTXCID40132894
228-153-0
ozfpsoblqzpiav-uhfffaoysa-n
MFCD00005673
MLS003373832
5-Nitro-1H-indole; NSC 520594;
5-nitro indole
2HU
5-Nitroindole, 98%
Oprea1_492280
SCHEMBL28686
CHEMBL164651
SCHEMBL17347355
BCP00104
CS-D1052
STR04237
BBL101309
NSC520594
STL555105
AKOS005199981
AKOS025395640
AB00487
AC-7395
FN07841
PS-3152
HY-59273
SMR002048627
SY006010
5-Nitroindole, purum, >=97.0% (TLC)
DB-031788
A8522
N0400
NS00034693
EN300-39249
A833241
Q27285232
F8889-7938
Z382696860