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5-Nitro-3-(1-piperidylmethyl)-1H-indole

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Identification
Molecular formula
C14H15N3O2
CAS number
NA
IUPAC name
5-nitro-3-(1-piperidylmethyl)-1H-indole
State
State

At room temperature, 5-Nitro-3-(1-piperidylmethyl)-1H-indole is typically in a solid state. It is often found as a crystalline powder and should be stored in a cool, dry place to maintain its stability. The solid nature allows it to be handled with appropriate laboratory safeguards, avoiding exposure to moisture and light.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
410.70
Boiling point (Kelvin)
683.90
General information
Molecular weight
301.34g/mol
Molar mass
301.3430g/mol
Density
1.3045g/cm3
Appearence

5-Nitro-3-(1-piperidylmethyl)-1H-indole typically appears as a crystalline solid that may vary in color depending on purity and specific conditions. The presence of the nitro group may impart a yellowish tint to the crystals.

It's important to handle the compound under proper safety conditions as it may be sensitive to light and moisture, potentially altering its appearance over time if not stored correctly.

Comment on solubility

Solubility of 5-nitro-3-(1-piperidylmethyl)-1H-indole

The solubility of 5-nitro-3-(1-piperidylmethyl)-1H-indole can be influenced by several factors, including its molecular structure and the solvent used. Understanding its solubility profile is essential for various applications, such as drug formulation and chemical synthesis. Here are some key points to consider:

  • Solvent Polarity: Typically, compounds with polar functional groups tend to dissolve better in polar solvents such as water or alcohols. In contrast, non-polar regions may favor solubility in organic solvents.
  • pH Sensitivity: The solubility may vary significantly with changes in pH, especially if the compound contains functional groups that can accept or donate protons, which may enhance solubility.
  • Temperature Effects: Temperature can play a crucial role, where increasing temperature generally improves solubility for most solid compounds.
  • Hydrogen Bonding: The presence of nitrogen in the piperidine ring may contribute to hydrogen bonding, which could influence how well it interacts with a particular solvent.

It is often stated that "the solubility of a compound is a window into its chemical behavior." Therefore, researching the exact solubility of 5-nitro-3-(1-piperidylmethyl)-1H-indole in various solvents provides valuable insights into its potential applications. The knowledge of how it dissolves can be pivotal in predicting its biological activity and therapeutic efficacy.

Interesting facts

Interesting Facts about 5-nitro-3-(1-piperidylmethyl)-1H-indole

5-nitro-3-(1-piperidylmethyl)-1H-indole is a compound that has garnered attention in the realm of medicinal chemistry due to its intriguing structure and potential applications. Here are some notable points about this compound:

  • Complex Structure: The compound features a piperidine ring, which is notable for its presence in numerous pharmaceuticals. This structural characteristic often contributes to the compound's biological activity.
  • Biological Activity: Research has indicated that indole derivatives, like this one, are often studied for their antidepressant and antipsychotic effects. Their relevance in neuropharmacology makes them significant in drug development.
  • Nitro Group Influence: The presence of a nitro group in the 5-position may enhance the compound’s reactivity and interacts with various biological targets. Nitro-functional groups can often affect the compound's properties and activities in unexpected ways.
  • Exciting Research Prospects: Compounds like 5-nitro-3-(1-piperidylmethyl)-1H-indole are crucial in the quest for novel therapeutics, particularly in the treatment of neurological disorders and cancers.
  • Synthesis Challenges: The synthesis of such complex molecules can be challenging and often requires various advanced organic chemistry techniques, making them a subject of study in synthetic methodology.

Overall, 5-nitro-3-(1-piperidylmethyl)-1H-indole stands out in the field of chemical research due to its promising applications, intricate structure, and the stimulating challenges it presents in synthesis. As research continues, compounds like this may pave the way for exciting advancements in medicinal chemistry.

Synonyms
3414-69-5
5-nitro-3-(piperidin-1-ylmethyl)-1H-indole
3-(1-PIPERIDINYLMETHYL)-5-NITRO-1H-INDOLE
INDOLE, 5-NITRO-3-(PIPERIDINOMETHYL)-
5-nitro-3-[(piperidin-1-yl)methyl]-1H-indole
BRN 0425671
5-Nitro-3-(piperidinomethyl)indole
5-Nitro-3-(1-piperidinylmethyl)-1H-indole
DTXSID90187733