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Nificazole

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Identification
Molecular formula
C8H4N2O4
CAS number
2268-05-1
IUPAC name
5-nitroisoindoline-1,3-dione
State
State

At room temperature, Nificazole is typically a solid. It is insoluble in water, which makes it stable under various atmospheric conditions unless heated beyond its melting point.

Melting point (Celsius)
278.00
Melting point (Kelvin)
551.15
Boiling point (Celsius)
504.15
Boiling point (Kelvin)
777.30
General information
Molecular weight
204.13g/mol
Molar mass
206.1380g/mol
Density
1.5840g/cm3
Appearence

Nificazole appears as a yellow crystalline powder. It is typically used in laboratories and may have a slight odor depending on its purity and formation environment. The compound can form crystals that are often opaque.

Comment on solubility

Solubility of 5-nitroisoindoline-1,3-dione

The solubility of 5-nitroisoindoline-1,3-dione in various solvents showcases its unique chemical interactions and structural characteristics. Here are some important points regarding its solubility:

  • Solvent Dependence: Typically soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol, while showing limited solubility in water.
  • Polarity Factors: The polar nitro group enhances solubility in polar solvents but impedes it in nonpolar solvents.
  • Temperature Influence: Solubility often increases with temperature, which can facilitate the dissolution process in various applications.
  • Concentration Effects: Higher concentrations of 5-nitroisoindoline-1,3-dione can lead to a decrease in solubility due to potential precipitation.

In summary, the solubility of 5-nitroisoindoline-1,3-dione is characterized by its affinity for polar solvents and significant variability based on temperature and concentration, making it a compound of interest for various chemical applications.

Interesting facts

Interesting Facts about 5-nitroisoindoline-1,3-dione

5-nitroisoindoline-1,3-dione is a fascinating compound that belongs to the class of isoindoline derivatives, known for their broad applications in the fields of chemistry and pharmaceuticals. Here are some key insights:

  • Unique Structure: This compound features a fused bicyclic structure, making it a vital component in the synthesis of various organic compounds.
  • Nitro Group Influence: The presence of the nitro group (–NO2) significantly enhances the compound's reactivity, which is instrumental in designing pharmaceuticals with improved efficacy.
  • Mechanism of Action: Compounds like 5-nitroisoindoline-1,3-dione can modulate biological pathways, potentially acting as precursors or intermediates in the synthesis of more complex molecules.
  • Research Potential: It is often studied for its role in medicinal chemistry, particularly in the development of drugs targeting various diseases, including cancer and bacterial infections.
  • Colorimetric Applications: The compound can show distinct color changes upon reaction with other substances, which makes it a candidate for use in colorimetric assays.

As scientists continue to explore the potential applications of 5-nitroisoindoline-1,3-dione, it is clear that its unique properties and structural characteristics hold promise for future innovations in synthetic and medicinal chemistry. “The ability to manipulate small molecules can lead to breakthroughs in treatment and understanding of complex biological systems,” as one researcher noted.

Synonyms
4-NITROPHTHALIMIDE
89-40-7
5-nitroisoindoline-1,3-dione
5-Nitro-1H-isoindole-1,3(2H)-dione
Phthalimide, 4-nitro-
1H-Isoindole-1,3(2H)-dione, 5-nitro-
5-nitroisoindole-1,3-dione
5-Nitrophthalimide
CCRIS 4685
5-nitro-2,3-dihydro-1H-isoindole-1,3-dione
NSC 5394
EINECS 201-905-5
UNII-26NA19UI3U
MFCD00005884
4-nitro-phthalimide
BRN 0180224
26NA19UI3U
DTXSID1025776
AI3-00701
NSC-5394
DTXCID405776
5-21-11-00158 (Beilstein Handbook Reference)
5-nitro-phthalimide
4-Nitrophthalimide, 98%
Oprea1_866451
1H-Isoindole-1, 5-nitro-
SCHEMBL151957
5-nitro-isoindole-1,3-dione
CHEMBL1607202
SCHEMBL16303093
NSC5394
BCP30589
Tox21_200190
STK397451
AKOS000313129
AS-9405
CS-W023085
FN58880
SB64042
CAS-89-40-7
NCGC00091620-01
NCGC00091620-02
NCGC00257744-01
AC-10997
SY039319
5-Nitro-1H-isoindole-1,3(2H)-dione #
N0247
NS00039328
EN300-16888
D70991
AE-641/30105047
SR-01000397641
4-NITRO-1,2-BENZENEDICARBOXYLICACID, IMIDE
SR-01000397641-1
Q27254119
Z56812733
F0345-4666
5-Nitro-1H-isoindole-1,3(2H)-dione;5-Nitroisoindoline-1,3-dione
5-nitroisoindoline-1,3-dione;5-Nitro-1H-isoindole-1,3(2H)-dione;Phthalimide, 4-nitro-
201-905-5