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5-Nitro-8-quinolinol

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Identification
Molecular formula
C9H6N2O3
CAS number
607-35-2
IUPAC name
5-nitroquinolin-8-ol
State
State

At room temperature, 5-Nitro-8-quinolinol is found as a solid, typically in a crystalline powder form, reflecting its stability and solid-state structure which is common for nitro derivatives of aromatic compounds.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
282.00
Boiling point (Kelvin)
555.15
General information
Molecular weight
190.16g/mol
Molar mass
190.1570g/mol
Density
1.4110g/cm3
Appearence

5-Nitro-8-quinolinol appears as a yellow crystalline powder. It is often used in scientific research and may exhibit a distinctive yellow color due to the presence of the nitro group which can influence its electronic structure and spectroscopic properties.

Comment on solubility

Solubility of 5-nitroquinolin-8-ol

5-nitroquinolin-8-ol, a compound characterized by its unique structure, presents intriguing solubility properties that are essential for various applications in chemistry and biology. Understanding the solubility of this compound is crucial, as it influences its bioavailability and reactivity.

General Solubility Characteristics

  • Solvent Dependence: The solubility of 5-nitroquinolin-8-ol can vary significantly depending on the solvent used. This compound typically shows improved solubility in polar solvents like methanol and ethanol.
  • Hydrophobicity: Due to its quinoline structure, it exhibits some hydrophobic characteristics, which may limit its solubility in aqueous environments.
  • Temperature Influence: The solubility of 5-nitroquinolin-8-ol often increases with temperature, allowing for greater dissolution in solvents when heated.

Factors Affecting Solubility

  • pH Levels: The solubility is also influenced by the pH of the solution, as ionization can play a significant role in its overall solubility profile.
  • Presence of Other Compounds: The presence of salts or other solutes can impact the solubility of 5-nitroquinolin-8-ol, often through the \"common ion effect\" or complex formation.

In summary, the solubility of 5-nitroquinolin-8-ol is multifaceted and depends on several factors including the solvent choice, temperature, pH, and environmental conditions. Continuous research into its solubility aspects is necessary to harness its full potential in chemical applications.

Interesting facts

Interesting Facts about 5-Nitroquinolin-8-ol

5-Nitroquinolin-8-ol is a fascinating chemical compound with a rich history in both organic chemistry and medicinal research. Here are some intriguing details about this compound:

  • Structure and Functionality: This compound features a unique quinoline skeleton that includes both a nitro group and a hydroxyl group. This combination allows it to exhibit interesting biochemical behavior.
  • Biological Significance: 5-Nitroquinolin-8-ol has been studied for its potential as an antimicrobial agent. Its ability to inhibit bacterial growth makes it a subject of interest in the field of microbiology.
  • Research Application: Scientists are keen on exploring the compound's properties in drug development, particularly for treating various infections and possibly cancer therapies. The compound may serve as a lead structure for the development of new antibiotics.
  • Fluorescence: The compound demonstrates interesting fluorescence properties, making it a potential candidate for use in biological imaging techniques. This can enhance visualization in biological assays.
  • Environmental Studies: Due to its chemical structure, 5-nitroquinolin-8-ol is also being investigated for possible environmental applications, especially in the field of water purification and treatment.

The exploration of 5-nitroquinolin-8-ol highlights the intersection of chemistry, biology, and environmental science. Its diverse functionality not only underpins its importance in research but also reminds us of the critical role that synthetic compounds play in advancing healthcare and sustainable practices.

As one researcher aptly put it, "The compounds we study today hold the potential to solve tomorrow's challenges." This sentiment is a testament to the ongoing significance of chemical research in improving quality of life.

Synonyms
NITROXOLINE
5-nitroquinolin-8-ol
4008-48-4
8-Hydroxy-5-nitroquinoline
5-Nitro-8-hydroxyquinoline
5-Nitro-8-quinolinol
Nitroxolin
5-Nitrox
Noxibiol
Nibiol
Noxin
5-Nitroxine
5-Nitroks
5-NOK
5-Nitro-8-oxyquinoline
Nitroxolina
Nitroxolinum
Galinok
Isinok
5-Nitro-8-oxychinoline
Nicene Forte
Nitroxolinum [INN-Latin]
Nitroxolina [INN-Spanish]
Uro-Coli
BAS 58
Nitroxoline [INN:BAN:DCF]
NSC 74947
EINECS 223-662-4
Nitroxoline (TN)
NSC-74947
Nitrohydroxyquinoline
Nitroxoline (INN)
BRN 0166146
DTXSID4046284
UNII-A8M33244M6
CHEBI:67121
5-Nitro-quinolin-8-ol
NITROXOLINE [MI]
NITROXOLINE [INN]
A8M33244M6
Quinolin-8-ol, 5-nitro-
NITROXOLINE [MART.]
NITROXOLINE [WHO-DD]
DTXCID2026284
5-21-03-00297 (Beilstein Handbook Reference)
Nitroxolinum (INN-Latin)
Nitroxolina (INN-Spanish)
NITROXOLINE (MART.)
Nicene
223-662-4
inchi=1/c9h6n2o3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12
rjiwzdntcbhxal-uhfffaoysa-n
8-Quinolinol, 5-nitro-
5NOK
A-82
MLS000069750
SMR000059036
MFCD00006791
NCGC00160664-01
CAS-4008-48-4
Nitroxlina
HNQ
Nitroxoline (Standard)
3ai8
Opera_ID_204
5-Nitro-8hydroxyquinoline
Oprea1_594857
8-Hydroxy-5-nitro-chinoline
cid_19910
MLS001148594
SCHEMBL151248
REGID_for_CID_19910
WLN: T66 BNJ GNW JQ
CHEMBL1454910
BDBM64987
HY-B1159R
GLXC-20116
HMS2230I14
HMS3264C05
HMS3374D08
KUC105356N
Pharmakon1600-01506173
8-Hydroxy-5-nitroquinoline, 96%
HY-B1159
NSC74947
Tox21_111969
KSC-8-140
NSC760393
NSC832678
s4591
STK099582
AKOS001053242
Tox21_111969_1
AC-7828
CCG-213981
CS-4761
DB01422
FN35484
NSC-760393
NSC-832678
PS-5547
NCGC00160664-03
DB-049530
A6696
H0805
NS00004195
EN300-17364
D07245
5-Nitro-8-quinolinol;8-Hydroxy-5-nitroquinoline
5-Nitro-8-quinolinol|5-Nitro-8-hydroxyquinoline
AB00572598_14
AG-205/04556035
Q304570
SR-01000721863
SR-01000721863-4
BRD-K97534525-001-23-5
BRD-K97534525-001-24-3
Z56922155