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5-Nitroquinoline-2-carboxylic acid

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Identification
Molecular formula
C10H6N2O4
CAS number
607-21-0
IUPAC name
5-nitroquinoline-2-carboxylic acid
State
State

At room temperature, 5-nitroquinoline-2-carboxylic acid is found in a solid state, typically as crystalline powder.

Melting point (Celsius)
265.00
Melting point (Kelvin)
538.15
Boiling point (Celsius)
-539.15
Boiling point (Kelvin)
-266.00
General information
Molecular weight
232.17g/mol
Molar mass
232.1720g/mol
Density
1.5400g/cm3
Appearence

5-Nitroquinoline-2-carboxylic acid typically appears as a yellow crystalline powder. Its coloration is due to the nitro group, which often imparts yellow hues to aromatic compounds.

Comment on solubility

Solubility of 5-nitroquinoline-2-carboxylic acid

5-nitroquinoline-2-carboxylic acid, a compound with intriguing properties, exhibits varying solubility behavior depending on the solvent used. Its solubility is often characterized by the following key points:

  • Polar Solvents: This compound generally shows decent solubility in polar solvents like water and methanol. The presence of both the nitro group and the carboxylic acid enhances its interaction with polar molecules.
  • Non-Polar Solvents: In contrast, 5-nitroquinoline-2-carboxylic acid has limited solubility in non-polar solvents such as hexane or benzene. This is primarily due to its polar functional groups that do not favor interactions with non-polar compounds.
  • pH Influence: The solubility can also be affected by pH levels. In alkaline conditions, the carboxylic acid group may deprotonate, resulting in increased solubility due to the formation of a negatively charged species.

To summarize, the solubility of 5-nitroquinoline-2-carboxylic acid is significantly influenced by the nature of the solvent and the pH environment. Understanding these factors can enhance its applicability in various chemical reactions and processes.

Interesting facts

Interesting Facts about 5-Nitroquinoline-2-Carboxylic Acid

5-Nitroquinoline-2-carboxylic acid is a fascinating compound belonging to the quinoline family, which is notable for its diverse applications in organic chemistry and medicinal research. Here are some intriguing aspects of this compound:

  • Antimicrobial Properties: This compound has demonstrated interesting antimicrobial activity, making it a potential candidate for developing new antibiotics. Its unique structure enables it to target bacterial membranes effectively.
  • Role in Synthesis: In organic chemistry, 5-nitroquinoline-2-carboxylic acid serves as an important intermediate for synthesizing various more complex molecules, including pharmaceuticals and agrochemicals.
  • Research Focus: Scientists are continually researching this compound for its ability to act as a building block in drug discovery, particularly in the field of cancer treatment, given its capability to interact with numerous biological targets.
  • Binding Affinity: Studies reveal that the nitro group on the quinoline ring can enhance the binding affinity of the compound to certain biological molecules, playing a crucial role in its activity.
  • Environmental Relevance: Quinoline derivatives, including 5-nitroquinoline-2-carboxylic acid, are also studied for their environmental impact, particularly in relation to their persistence in ecosystems and their role in pollution.

In summary, 5-nitroquinoline-2-carboxylic acid exemplifies the intersection of organic synthesis and pharmaceutical development, highlighting the importance of exploring such compounds for advancements in medicine and environmental science.

Synonyms
5-Nitroquinoline-2-carboxylic acid
5-NITROQUINALDIC ACID
5-Nitroquinaldinic acid
5-Nitro-2-quinolinecarboxylic acid
Quinaldic acid, 5-nitro-
2-Quinolinecarboxylic acid, 5-nitro-
NSC 5339
EINECS 208-372-8
BRN 0188433
UNII-3D55B5O273
NSC-5339
3D55B5O273
NITROQUINALDIC ACID, 5-
DTXSID40200502
2-CARBOXY-5-NITROQUINOLINE
0-22-00-00073 (Beilstein Handbook Reference)
5-NITROQUINALDIC ACID [MI]
DTXCID00122993
2-Quinolinecarboxylic acid, 5-nitro-(9CI)
525-47-3
AKOS A0602-0498
SCHEMBL297995
NSC5339
5-Nitroquinoline-2-carboxylicacid
PHELEJSJZGCLEJ-UHFFFAOYSA-N
BBL034681
STL426752
AKOS000320054
SB70698
CS-0360846
NS00032524
9X-0857
SR-01000309518
SR-01000309518-1
Q27257055