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5-(o-tolyl)-1,3,4-oxadiazol-2-amine

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Identification
Molecular formula
C9H9N3O
CAS number
92659-57-3
IUPAC name
5-(o-tolyl)-1,3,4-oxadiazol-2-amine
State
State

At room temperature, 5-(o-tolyl)-1,3,4-oxadiazol-2-amine is in a solid state, typically existing as crystalline powder.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
384.00
Boiling point (Kelvin)
657.15
General information
Molecular weight
176.20g/mol
Molar mass
176.1980g/mol
Density
1.2100g/cm3
Appearence

The compound is typically a solid at room temperature and can appear as a crystalline powder. The color can vary from white to off-white, depending on the purity and specific conditions surrounding the sample.

Comment on solubility

Solubility of 5-(o-tolyl)-1,3,4-oxadiazol-2-amine

The solubility of 5-(o-tolyl)-1,3,4-oxadiazol-2-amine can be influenced by various factors, and it's interesting to analyze its behavior in different solvents. Generally, this compound is expected to exhibit the following characteristics:

  • Polarity: The presence of both aromatic and amine functional groups suggests a degree of polarity that could enhance solubility in polar solvents.
  • Solvent Interaction: This compound may show better solubility in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO), while being less soluble in nonpolar solvents like hexane or toluene.
  • pH Dependence: The solubility might also change with pH levels due to the amine group, which can be protonated under acidic conditions, potentially increasing its solubility in aqueous environments.
  • Temperature Effect: Increasing the temperature generally enhances solubility; thus, heating the solution may promote greater dissolution of this compound.

As a general observation, it is critical to consider the combination of factors that dictate solubility, as they can result in varied outcomes based on the chosen solvent system. The unique structure of 5-(o-tolyl)-1,3,4-oxadiazol-2-amine implies that solubility studies are essential for understanding its chemical behavior and potential applications.

Interesting facts

Interesting Facts about 5-(o-tolyl)-1,3,4-oxadiazol-2-amine

5-(o-tolyl)-1,3,4-oxadiazol-2-amine, a fascinating compound in the realm of organic chemistry, presents a multitude of intriguing aspects that capture the attention of scientists and students alike.

Structure and Classification

This compound belongs to the class of oxadiazoles, which are known for their five-membered ring structure containing nitrogen and oxygen atoms. The incorporation of an o-tolyl group adds a unique steric effect, enhancing its reactivity and interactions with other molecules.

Key Properties

Here are some key properties and applications to consider:

  • Pharmaceutical Potential: Compounds with oxadiazole structures have been widely studied for their medicinal properties, including antimicrobial and anti-inflammatory effects.
  • Material Science: The unique properties of oxadiazoles make them potential candidates for use in organic electronics and photonic devices.
  • Biochemical Activity: The presence of amine groups allows for participation in various biochemical reactions, contributing to their role in drug design.

Applications and Research

Researchers are keenly investigating 5-(o-tolyl)-1,3,4-oxadiazol-2-amine for its potential in:

  1. Synthetic Chemistry: As a versatile building block in synthetic pathways leading to more complex molecules.
  2. Drug Development: Its derivatives are being evaluated for therapeutic efficacy in treating various diseases.
  3. Study of Nitrogen Heterocycles: The compound exemplifies the rich chemistry of nitrogen-containing heterocycles, making it an interesting subject for further exploration.

In summary, 5-(o-tolyl)-1,3,4-oxadiazol-2-amine stands not just as a chemical entity but as a symbol of innovation and promise in various fields of scientific research. Its diverse applications and interesting structural features make it a compound worthy of attention and study.

Synonyms
1750-78-3
5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine
2-Amino-5-(o-tolyl)-1,3,4-oxadiazole
1,3,4-OXADIAZOLE, 2-AMINO-5-(o-TOLYL)-
DTXSID80169922
DTXCID4092413
866-117-1
5-(o-Tolyl)-1,3,4-oxadiazol-2-amine
1,3,4-Oxadiazol-2-amine, 5-(2-methylphenyl)-
2-amino-5-(2-methylphenyl)-1,3,4-oxadiazole
MFCD00652824
SCHEMBL13170400
ALBB-014853
AKOS000123155
AS-43477
DB-064984
CS-0448298
EN300-35984
Z285233846