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Rolipram

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Identification
Molecular formula
C16H21N2O3
CAS number
61413-54-5
IUPAC name
5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide
State
State

At room temperature, Rolipram is in a solid state. It is typically handled and stored as a solid crystalline substance.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.20
Boiling point (Celsius)
435.70
Boiling point (Kelvin)
708.90
General information
Molecular weight
275.33g/mol
Molar mass
275.3330g/mol
Density
1.3360g/cm3
Appearence

Rolipram typically appears as a white or off-white crystalline solid. It may be provided in a powdered form and is generally odorless.

Comment on solubility

Solubility of 5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide

The solubility of 5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide in various solvents can play a significant role in its applications and biological activity. Generally, its solubility profile can be influenced by several factors, including:

  • Polarity of the solvent: Due to the presence of the carboxamide group, this compound tends to exhibit better solubility in polar solvents such as water or ethanol.
  • Temperature: Like many organic compounds, solubility may increase with temperature, allowing for more significant dissolution in a given solvent.
  • pH of the solution: The ionization state of the carboxamide group can affect solubility, with changes in pH potentially enhancing or reducing solubility in aqueous environments.

Furthermore, it is important to note that:

  • The ability of the compound to form hydrogen bonds can enhance its solubility in polar solvents.
  • Solubility can vary considerably based on the specific conditions, such as ionic strength and presence of other solutes.

In summary, while the solubility of 5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide in different environments can be promising, experimental data is essential to establish specific solubility values and conditions. This knowledge is invaluable for its effective use in pharmaceutical and chemical applications.

Interesting facts

Interesting Facts about 5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide

5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide is a fascinating compound due to its unique structural features and potential applications in medicinal chemistry. Here are some intriguing aspects:

  • Cyclopropyl Influence: The inclusion of a cyclopropyl group, known for its strain and reactivity, often lends unique properties to the molecule that can enhance its interactions with biological targets.
  • Structural Diversity: This compound exemplifies how subtle changes in molecular structure can lead to significant variations in biological activity. The presence of both pyrrolidine and carbonyl functionalities contributes to this diversity.
  • Potential Therapeutic Applications: Due to its structural framework, compounds like this one have garnered interest for use in pharmaceuticals. They may exhibit activity against various neurological disorders or provide insights into new therapeutic strategies.
  • Chirality: The (1S) designation indicates that this compound is chiral, which can lead to different biological activities depending on the enantiomer. This has profound implications for drug design, as chiral molecules often have different effects in biological systems.
  • "The Devil is in the Details": Small changes in structure, such as endpoint functionalities and side groups, can dramatically influence pharmacodynamics and pharmacokinetics, making this compound intriguing for researchers.

As a compound that bridges the gap between synthetic organic chemistry and pharmacology, 5-oxo-N-[(1S)-2-phenylcyclopropyl]pyrrolidine-2-carboxamide serves as a prime example of the complexities involved in drug development. Its study underscores the essential role of molecular structure in determining biological interactions and therapeutic potential.