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5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine chloride

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Identification
Molecular formula
C16H18N3Cl
CAS number
74587-86-3
IUPAC name
5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine;chloride
State
State

At room temperature, this compound exists as a solid.

Melting point (Celsius)
269.00
Melting point (Kelvin)
542.15
Boiling point (Celsius)
485.00
Boiling point (Kelvin)
758.15
General information
Molecular weight
277.80g/mol
Molar mass
277.8010g/mol
Density
1.1800g/cm3
Appearence

This compound appears as a crystalline solid, which is white or off-white in color.

Comment on solubility

Solubility of 5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine; chloride

The solubility of 5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine; chloride is a topic of interest due to its potential applications in various fields, including pharmaceuticals. Generally, this compound is observed to have the following solubility characteristics:

  • Polar Solvents: It tends to be soluble in polar solvents such as water and methanol. This is likely due to the presence of the carboxamidine functional group, which can engage in hydrogen bonding with water molecules.
  • Non-Polar Solvents: In contrast, its solubility in non-polar solvents like hexane is minimal. Non-polar solvents lack the capacity to interact through hydrogen bonding, making it difficult for the compound to dissolve.
  • pH Sensitivity: The solubility may be affected by the pH of the solution. For example, at acidic pH levels, protonation of the amine group may enhance solubility.

In summary, the solubility of this compound can be attributed to intermolecular interactions, particularly hydrogen bonding, which enhances its affinity for polar environments. Understanding the solubility behaviors of 5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine; chloride is crucial for designing effective formulations in medicinal chemistry.

Interesting facts

Exploring 5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine;chloride

5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine;chloride is a fascinating compound worth delving into, particularly for its unique structure and potential applications in the field of medicinal chemistry. This compound is part of the isoquinoline family, which is known for its diverse biological activities.

Unique Features

  • Isoquinoline Framework: The presence of the isoquinoline skeleton is of great interest in pharmacology. It often forms the basis for many important bioactive molecules.
  • Carboxamidine Group: The carboxamidine moiety introduces intriguing properties, particularly in terms of interaction with biological targets.
  • Chloride Salt Form: The chloride form can enhance solubility and stability, which is essential for various applications, including in drug formulation.

Potential Applications

This compound has caught the attention of chemists and biologists alike, with potential applications in:

  • Pharmaceutical Development: The unique structural elements might contribute to novel drug discovery pathways.
  • Nerve Receptor Studies: This compound can be explored for its effects on specific neural receptors and pathways.
  • Anti-cancer Research: Like many isoquinoline derivatives, it has potential as an anti-cancer agent, making it a valuable subject for ongoing investigations.

Scientific Curiosity

The intricate combination of the tetrahydroisoquinoline structure and the carboxamidine functionality prompts questions such as:

  1. What biological activities can be attributed to this compound?
  2. How does the presence of the phenyl group influence its reactivity and interactions?
  3. Can modifications to the core structure yield more potent derivatives?

In conclusion, 5-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-carboxamidine;chloride serves as a vital compound in various research domains. Its complex architecture holds the promise of unlocking new therapeutic avenues, making it a topic ripe for further exploration.

Synonyms
2(1H)-ISOQUINOLINECARBOXAMIDINE, 3,4-DIHYDRO-5-PHENYL-, HYDROCHLORIDE
24464-17-3
RefChem:1058649
5-Phenyl-3,4-dihydro-2(1H)-isoquinolinecarboxamidine hydrochloride