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5-Phenyl-1,3-benzoxazole-2-thiol

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Identification
Molecular formula
C13H9NOS
CAS number
39987-31-8
IUPAC name
5-phenyl-1,3-benzoxazole-2-thiol
State
State

At room temperature, 5-Phenyl-1,3-benzoxazole-2-thiol is in a solid state, generally in the form of a crystalline powder.

Melting point (Celsius)
115.30
Melting point (Kelvin)
388.45
Boiling point (Celsius)
342.90
Boiling point (Kelvin)
616.05
General information
Molecular weight
227.27g/mol
Molar mass
227.2730g/mol
Density
1.3225g/cm3
Appearence

5-Phenyl-1,3-benzoxazole-2-thiol is typically a yellowish crystalline solid. Its crystalline form is often fine and powdery and can sometimes appear as a solid mass. It may also emit a faint odor.

Comment on solubility

Solubility of 5-phenyl-1,3-benzoxazole-2-thiol

When it comes to the solubility of 5-phenyl-1,3-benzoxazole-2-thiol, several factors come into play that can influence its behavior in various solvents.

  • Polarity: The presence of the thiol group (-SH) in the structure can enhance the solubility of this compound in polar solvents such as water. However, the bulky phenyl group may create steric hindrance, reducing overall solubility.
  • Solvation Effects: In organic solvents like ethanol, acetone, or dimethyl sulfoxide (DMSO), solubility tends to be increased due to favorable interactions between the solvent molecules and the functional groups of the compound.
  • Temperature Influence: As with many organic compounds, increasing temperature can enhance solubility. Higher temperatures generally provide more kinetic energy, allowing molecules to overcome intermolecular forces.
  • pH Sensitivity: The solubility of 5-phenyl-1,3-benzoxazole-2-thiol could also be affected by the pH of the solution, as thiol groups can undergo protonation or deprotonation based on the acidity of the environment.

To sum up, while 5-phenyl-1,3-benzoxazole-2-thiol may exhibit some degree of solubility in polar solvents, its overall solubility profile is likely to be complex and dependent on various external factors. It is vital to conduct experimental assessments to determine its solubility in specific conditions, as "the world of solubility is full of surprises."

Interesting facts

Interesting Facts about 5-Phenyl-1,3-benzoxazole-2-thiol

5-Phenyl-1,3-benzoxazole-2-thiol is a fascinating compound that belongs to the class of benzoxazoles, which are widely recognized for their diverse biochemical activities and applications. Here are some intriguing aspects of this compound:

  • Biological Activity: This compound exhibits interesting biological properties, including potential antimicrobial and anticancer activities. Research has indicated that derivatives of benzoxazoles can inhibit the growth of various cancer cell lines.
  • Fluorescent Properties: 5-Phenyl-1,3-benzoxazole-2-thiol is known for its ability to fluoresce, making it useful in various chemical and biological assays. Its fluorescent characteristics can be leveraged in microscopy and imaging studies.
  • Design and Synthesis: The synthesis of benzoxazole derivatives involves several methodologies, including condensation reactions and cyclization processes. The presence of the thiol group in this compound enhances its reactivity, allowing further chemical modifications and applications.
  • Applications: This compound plays a role in the development of optical brighteners, dyes, and sensors. Its unique structural features enable its use in designing materials with specific photoluminescent properties.
  • Research Significance: Due to its promising pharmacological properties, 5-phenyl-1,3-benzoxazole-2-thiol has become a subject of significant research interest, opening avenues for drug development and biochemistry.

In summary, the world of 5-phenyl-1,3-benzoxazole-2-thiol is rich with potential, making it an exciting topic for scientists and chemists alike. Its biological activities, fluorescent properties, and diverse applications underscore the importance of exploring such compounds in chemical research.