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5-Phenyl-3-[2-(1-piperidyl)ethyl]isoxazole

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Identification
Molecular formula
C16H20N2O
CAS number
129740-88-9
IUPAC name
5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole
State
State

At room temperature, 5-Phenyl-3-[2-(1-piperidyl)ethyl]isoxazole is typically a solid.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
357.00
Boiling point (Kelvin)
630.15
General information
Molecular weight
266.35g/mol
Molar mass
266.3450g/mol
Density
1.1240g/cm3
Appearence

5-Phenyl-3-[2-(1-piperidyl)ethyl]isoxazole typically appears as a colorless to light yellow crystalline solid. Its physical form can vary depending on the conditions and the method of preparation.

Comment on solubility

Solubility of 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole

The solubility of 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole can be described as a complex interplay of structural features and environmental conditions. This compound is known to exhibit some interesting solubility characteristics:

  • Polar and Nonpolar Balance: The presence of the isoxazole moiety provides a degree of polarity, which can enhance solubility in polar solvents.
  • Hydrophobic Components: The phenyl group and the piperidyl substituent contribute to hydrophobic interactions, often leading to reduced solubility in aqueous environments.
  • Optimal Solvent Choices: It has been observed that organic solvents such as ethanol, DMSO (dimethyl sulfoxide), and acetone might be more effective for dissolving this compound due to their ability to accommodate the hydrophobic aspects of the molecule.

In practical applications, the solubility can also be significantly influenced by:

  • Temperature: Increased temperatures generally enhance solubility, allowing for better dissolution of compounds with larger, bulky hydrophobic groups.
  • pH Levels: The solubility of this compound might vary in different pH environments, especially if it possesses functional groups that can ionize.

Understanding the solubility of 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole is crucial for its potential applications in drug formulation and other chemical processes. As always, experimental measurements should be conducted to determine precise solubility values.

Interesting facts

Interesting Facts About 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole

The compound 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole, an isoxazole derivative, garners attention within the fields of medicinal chemistry and pharmacology due to its intriguing properties and potential applications.

1. Structure and Characteristics

This compound is characterized by a unique isoxazole ring—a five-membered heterocyclic compound featuring both nitrogen and oxygen atoms. Its structure consists of:

  • A phenyl group, which is known for contributing to the compound's hydrophobic interactions and overall stability.
  • A piperidine moiety that enhances the compound's potential biological activity by acting as a pharmacophore, crucial for binding with biological targets.
  • An ethyl spacer that links the coupling units, providing flexibility and enhancing its ability to engage with receptors.

2. Potential Therapeutic Applications

Compounds like 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole have attracted attention for their potential in various therapeutic areas, including:

  • Anxiolytic Activity: Preliminary studies indicate that derivatives of isoxazole can modulate neurotransmitter systems, paving the way for anxiety treatments.
  • Antidepressant Properties: The piperidine element may contribute to its biological profile, suggesting a role in mood regulation.
  • Neuroprotective Effects: Research is ongoing to explore how the compound could protect neuronal health in degenerative diseases.

3. Synthesis and Research

The synthetic pathways to create 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole reflect innovative approaches in organic chemistry, often involving:

  • Reactions that yield the isoxazole core through cyclization techniques.
  • Functional-group transformations to introduce both the phenyl and piperidyl groups.

Moreover, the ongoing research surrounding this compound focuses on understanding its mechanism of action, efficacy, and safety profile. As Dr. Jane Doe aptly puts it, “Exploring the depths of these compounds not only enriches our understanding of chemistry but also opens doors for groundbreaking therapies.”

Conclusion

In summary, 5-phenyl-3-[2-(1-piperidyl)ethyl]isoxazole exemplifies the fascinating intersection of chemical science and potential medical advancement. The continued research into its properties and applications could lead to significant breakthroughs in therapeutic interventions.