Skip to main content

5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole

ADVERTISEMENT
Identification
Molecular formula
C14H16N2O
CAS number
163863-89-2
IUPAC name
5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole
State
State

The compound is typically a solid at room temperature, reflecting its crystalline nature and high melting point.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
398.60
Boiling point (Kelvin)
671.80
General information
Molecular weight
256.30g/mol
Molar mass
256.3030g/mol
Density
1.1912g/cm3
Appearence

The compound appears as a white to off-white crystalline solid. It is often used in chemical synthesis and research applications.

Comment on solubility

Solubility of 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole

The solubility of 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole can be quite intriguing and varies depending on the solvent used. Understanding its solubility properties can provide insights into its potential applications and behavior in various environments.

Factors Influencing Solubility

Several factors can influence the solubility of this compound, including:

  • Polarity of the Solvent: Generally, polar solvents tend to dissolve polar compounds better, while nonpolar solvents will do so for nonpolar compounds. The presence of both isoxazole and pyrrolidine groups can create opportunities for solubility in different media.
  • Temperature: As temperature increases, the solubility of most solids in liquids can also increase, making it important to consider thermal conditions when assessing solubility.
  • pH Levels: The ionization state of the compound can change with pH, particularly if the compound contains functional groups that can donate or accept protons, thus affecting solubility.

Practical Considerations

When trying to dissolve 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole, it is essential to consider:

  • Compatible Solvents: Testing in solvents such as ethanol, methanol, or even dimethyl sulfoxide (DMSO) can be beneficial.
  • Concentration Limits: Understanding the maximum concentration that can be achieved in a given solvent is crucial for practical applications.
  • Use in Formulations: Specific solubility characteristics will aid in its formulation in pharmaceuticals or materials science applications.

Overall, while the solubility of 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole may not be extensively documented, its behavior in various solvents is particularly important and warrants further exploration to unlock its full potential.

Interesting facts

Interesting Facts about 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole

5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole is a fascinating compound that belongs to the isoxazole family, which is known for its unique five-membered ring structure. Here are some intriguing insights into this compound:

  • Structure and Functionality: The isoxazole ring in this compound is enriched by a phenyl group and a pyrrolidin-1-ylmethyl substituent. This creates a diverse set of functional groups that can interact with various biological targets, making it an essential focus in medicinal chemistry.
  • Biological Significance: Compounds like 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole are often explored for their potential pharmacological properties. Research suggests they might have applications in treating neurological disorders due to their influence on neurotransmitter systems.
  • Intriguing Synthesis: The synthesis of isoxazole derivatives involves innovative reactions, including cycloadditions and rearrangements. This compound can often be synthesized through the reaction of α,β-unsaturated carbonyl compounds with hydrazines and nitriles, showcasing a complex interplay of organic chemistry techniques.
  • Research Applications: Scientists are increasingly interested in how modifications of the isoxazole structure, such as those found in 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole, can optimize drug efficacy. Structure-activity relationship (SAR) studies continue to reveal the significance of substituents on biological activity.
  • Potential Thermochemical Properties: Compounds in the isoxazole family may exhibit unique thermochemical behavior, such as potential isomerization under specific conditions. This could lead to varied reactivity and performance in biological systems.

In conclusion, the study of 5-phenyl-3-(pyrrolidin-1-ylmethyl)isoxazole not only emphasizes the intricate nature of organic compounds but also highlights the vital role they play in developing therapeutic agents. As research continues to advance, we may uncover even more fascinating aspects of this compound.