5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine

Identification

Molecular formula

C₁₆H₁₇N₃

CAS number

1044711-28-8

IUPAC name

5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine

State

At room temperature, 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine is typically a solid. This solid state is due to the compound's relatively high molecular weight and intermolecular forces.

Melting point (Celsius)

147.80

Melting point (Kelvin)

420.95

Boiling point (Celsius)

311.20

Boiling point (Kelvin)

584.35

General information

Molecular weight

236.30g/mol

Molar mass

236.2990g/mol

Density

1.2000g/cm³

Appearence

5-Phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine often presents as a white to off-white crystalline powder. This appearance is typical for many crystalline organic compounds that have a high degree of purity.

Comment on solubility

Solubility of 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine

The solubility of 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine in various solvents presents a compelling case for investigation. Understanding the solubility profile is crucial for applications in both pharmaceutical developments and chemical research.

In general, the solubility of this compound can be influenced by several factors, including:

Polarity of the Solvent: Polar solvents such as water or methanol may show varying levels of solubility compared to non-polar solvents like hexane.
Temperature: Increased temperature often leads to higher solubility for many organic compounds.
pH Levels: The acid-base properties of the solution can significantly affect solubility, especially given the presence of the carboxamidine group.
Presence of Co-Solvents: Sometimes, adding another substance can enhance solubility through a synergistic effect.

It is often noted that compounds with aromatic rings, such as this one, can demonstrate moderate solubility due to their hydrophobic character, yet the potential for solvation effects from the amine functional group could lead to interesting results. Thus, researchers might observe:

Higher solubility in organic solvents like dimethyl sulfoxide (DMSO) or ethanol.
Lower solubility in water, although complexation with certain agents can sometimes improve this.

In conclusion, the solubility characteristics of 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine serve as a vital aspect in its practical applications and further investigation is encouraged to fully grasp its dissolution behavior in different environments.

Interesting facts

5-Phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine

5-Phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine is a fascinating compound that showcases the intricate relationships between structure and biological activity. This compound is part of the isoquinoline family, which is known for its diverse range of pharmacological properties. Here are some interesting aspects of this compound:

Structural Significance: The isoquinoline core features a bicyclic structure that contributes to its unique chemical reactivity. The presence of the phenyl group further enhances its ability to interact with biological targets.

Pharmacological Potential: Compounds related to isoquinolines have been extensively studied for their potential medicinal uses, such as anti-cancer, anti-inflammatory, and analgesic properties. This class of compounds continues to be a focus of research in drug development.

Synthesis: Synthesis of 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine may involve innovative organic chemistry techniques. The methodology often includes the use of various catalysts and reagents designed to achieve high yields and purities.

Research Applications: In the laboratory, this compound can be used as a building block for the synthesis of more complex molecules. Its derivatives could be valuable in exploring new therapeutic avenues.

As we delve deeper into the world of isoquinolines, compounds like 5-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine challenge us to uncover their full potential and the biochemical mechanisms that underpin their activity. The marriage of chemical structure and biological function continues to inspire scientists, pushing the boundaries of medicinal chemistry.