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5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine

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Identification
Molecular formula
C16H13ClF3N3O
CAS number
74058-71-2
IUPAC name
5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine
State
State
At room temperature, this compound is typically in a crystalline solid state.
Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
385.00
Boiling point (Kelvin)
658.15
General information
Molecular weight
318.30g/mol
Molar mass
318.3020g/mol
Density
1.3300g/cm3
Appearence

This compound typically appears as a crystalline solid, which might present in a variety of colors depending on its purity and preparation method.

Comment on solubility

Solubility of 5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine

The solubility of 5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine is influenced by various factors, including its molecular structure and the presence of functional groups. This compound is a member of the benzodiazepine family, which is known for varying degrees of solubility in different solvents.

Here are some key points about its solubility:

  • Polar vs. Non-Polar Solvents: Given the presence of the trifluoromethoxy group, this compound may exhibit greater solubility in polar organic solvents compared to non-polar solvents.
  • Hydrogen Bonding: The benzodiazepine structure can potentially facilitate hydrogen bonding with solvents, enhancing its solubility in suitable environments.
  • Practical Applications: Understanding the solubility of this compound is crucial for its applications in pharmaceuticals, where solubility can affect bioavailability and therapeutic efficacy.
  • Temperature Effects: As with many substances, solubility may increase with temperature, making it essential to consider thermal conditions in practical scenarios.

In conclusion, while the solubility of 5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine can be impacted by its structural characteristics and the solvent used, more specific data would be essential for precise applications. A thorough solubility study is recommended to optimize its use in various formulations.

Interesting facts

Interesting Facts about 5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine

5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine, a member of the benzodiazepine family, presents interesting properties and potential applications in medicinal chemistry. Here are some noteworthy points regarding this intriguing compound:

  • Unique Structural Features: This compound contains a trifluoromethoxy group, which significantly affects its pharmacological properties and enhances its lipophilicity.
  • Therapeutic Potential: Benzodiazepines, including this compound, are known for their sedation, anxiolytic, and muscle relaxant effects. This specific compound is being explored for its potential in treating anxiety disorders.
  • Mechanism of Action: The compound functions by modulating the GABAA receptor, which plays a crucial role in inhibitory neurotransmission in the brain. By enhancing the action of GABA, it may help alleviate symptoms related to anxiety and stress.
  • Research Interests: Scientists are keenly interested in investigating the compound’s binding affinity and selectivity toward various receptor subtypes, which can lead to discoveries of more targeted therapies with fewer side effects.
  • Fluorine's Influence: The presence of fluorine atoms in the trifluoromethoxy group can often lead to increased metabolic stability and bioavailability, making the compound a candidate for further pharmacological study.

In summary, 5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine exemplifies the complexity and significance of benzodiazepine derivatives in drug development. As research advances, this compound may unlock novel therapeutic avenues in the management of mental health disorders. As the famous chemist Linus Pauling once stated, "The best way to have a good idea is to have lots of ideas." This statement is quite applicable in the exploration of new compounds like this one, highlighting the ongoing quest to innovate in the field of medicinal chemistry.

Synonyms
19337-66-7
BRN 1595445
1H-1,4-BENZODIAZEPINE, 2,3-DIHYDRO-5-PHENYL-7-TRIFLUOROMETHOXY-
2,3-Dihydro-5-phenyl-7-trifluoromethoxy-1H-1,4-benzodiazepine
DTXSID60172934
5-23-12-00371 (Beilstein Handbook Reference)
DTXCID4095425
RefChem:237128
2,3-Dihydro-5-phenyl-7-(trifluoromethoxy)-1H-1,4-benzodiazepine
5-phenyl-7-(trifluoromethoxy)-2,3-dihydro-1H-1,4-benzodiazepine