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5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine

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Identification
Molecular formula
C16H12F3N2
CAS number
/
IUPAC name
5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine
State
State

At room temperature, 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine is in solid state. It is commonly encountered as a powder or in crystalline form, suitable for chemical synthesis and pharmaceutical applications.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
282.26g/mol
Molar mass
282.2590g/mol
Density
1.3100g/cm3
Appearence

5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine appears as a crystalline solid. The compound's specific crystalline structure may contribute to its appearance, making it suitable for use in applications requiring precise molecular configurations.

Comment on solubility

Solubility of 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine

The solubility of 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine can be influenced by several factors, making it an intriguing compound to study. Being part of the benzodiazepine family, its behavior in various solvents often exhibits noteworthy characteristics:

  • Polar vs. Non-Polar Solvents: This compound may show differential solubility in polar solvents (like water) compared to non-polar solvents (like hexane). Typically, **benzodiazepines** are better soluble in organic solvents due to their non-polar aromatic rings.
  • Influence of Trifluoromethyl Group: The presence of the trifluoromethyl group (-CF3) can significantly affect the polar interactions, often increasing hydrophobicity, which may reduce water solubility but enhance solubility in organic media.
  • Temperature Dependence: As with many organic compounds, solubility can increase with temperature. Thus, higher temperatures frequently promote greater dissolution in organic solvents.

In summary, while the solubility of 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine may not be extensive in water, it likely demonstrates appreciable solubility in organic solvents such as ethanol or dichloromethane. This phenomenon underlines the importance of solvent choice when working with this compound and highlights the broader implications for its applications in various chemical processes.

Interesting facts

Interesting Facts about 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine

5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine is a fascinating compound that falls within the benzodiazepine family, renowned for its psychoactive properties. This particular compound is noteworthy for several reasons:

  • Pharmacological Significance: As a member of the benzodiazepine class, it may exhibit interesting interactions with the central nervous system, potentially leading to anxiolytic, sedative, and muscle-relaxant effects.
  • Fluorine Influence: The trifluoromethyl group is particularly intriguing because the addition of fluorine atoms can markedly influence the biological activity and lipophilicity of the compound, making it an interesting target for drug development.
  • Research Potential: This compound’s structure lends itself to extensive study, particularly in the realms of medicinal chemistry and pharmacology. Researchers often explore modifications of benzodiazepines to enhance efficacy and reduce side effects.
  • Structural Variability: The presence of the phenyl ring can contribute to a variety of substitution patterns, leading to a diverse library of compounds with potentially varying therapeutic benefits.

In essence, the study of 5-phenyl-7-(trifluoromethyl)-2,3-dihydro-1H-1,4-benzodiazepine not only enhances our understanding of the benzodiazepine class but also opens avenues for the development of new therapeutic agents. As stated by many in the field, "the journey of molecular modification is often where the magic happens." This compound exemplifies that journey and reminds us of the intricate connections between molecular structure and biological activity.

Synonyms
2,3-Dihydro-5-phenyl-7-(trifluoromethyl)-1H-1,4-benzodiazepine
BRN 0757483
RO-5-4933 free base
JZE935ZLA7
1H-1,4-BENZODIAZEPINE, 2,3-DIHYDRO-5-PHENYL-7-(TRIFLUOROMETHYL)-
UNII-JZE935ZLA7
DTXSID00183100
5-23-09-00075 (Beilstein Handbook Reference)
7-TRIFLUOROMETHYL-5-PHENYL-1,2-DIHYDRO(3H)-1,4-BENZODIAZEPINE
DTXCID70105591
2890-28-0
SCHEMBL11678875
UVIWKJUMUWEHQO-UHFFFAOYSA-N
Benzodiazepine, 1H-1,4-, 2,3-dihydro-5-phenyl-7-(trifluoromethyl)-