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γ-Valerolactone

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Identification
Molecular formula
C5H8O2
CAS number
108-29-2
IUPAC name
5-phenyltetrahydrofuran-2-one
State
State

At room temperature, γ-Valerolactone is in a liquid state. It is known for being miscible with water and many common organic solvents, making it a versatile solvent in various chemical reactions.

Melting point (Celsius)
-31.00
Melting point (Kelvin)
242.15
Boiling point (Celsius)
207.00
Boiling point (Kelvin)
480.15
General information
Molecular weight
112.13g/mol
Molar mass
112.1270g/mol
Density
1.1170g/cm3
Appearence

γ-Valerolactone is typically a colorless liquid that is characterized by its faint pleasant odor resembling that of caramel or fresh hay. Its appearance can occasionally be described as slightly oily.

Comment on solubility

Solubility of 5-Phenyltetrahydrofuran-2-one

5-Phenyltetrahydrofuran-2-one, a compound with interesting properties, exhibits variable solubility based on its structural characteristics. To provide a clearer understanding, consider the following points:

  • Polarity: The presence of the phenyl group influences its overall polarity, making it more soluble in organic solvents.
  • Solvent Compatibility: This compound shows good solubility in polar aprotic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), while its solubility in water is limited due to its hydrophobic qualities.
  • Temperature Effects: Solubility can vary significantly with temperature; typically, as temperature increases, solubility in organic solvents will also increase.
  • Interactions: The ability of 5-phenyltetrahydrofuran-2-one to solubilize depends on the presence of functional groups capable of hydrogen bonding when interacting with solvents.

In summary, while 5-phenyltetrahydrofuran-2-one is not highly soluble in water, its solubility in organic solvents can be considered favorable, making it versatile for various applications in organic chemistry. As always, it’s important to conduct solubility tests under specific conditions to gain the most accurate understanding of its behavior in different environments.

Interesting facts

Interesting Facts about 5-Phenyltetrahydrofuran-2-one

5-Phenyltetrahydrofuran-2-one, often referred to in scientific circles for its intriguing structure and potential applications, is a compound that belongs to the family of lactones. Its unique molecular configuration contributes to its reactivity and versatility in various chemical reactions. Here are some engaging insights into this compound:

  • Natural Occurrence: This compound is related to several naturally occurring substances, which suggests its role in biosynthetic pathways. These connections can often lead to interesting studies of plant metabolites.
  • Synthetic Utility: 5-Phenyltetrahydrofuran-2-one has been explored in synthetic organic chemistry for its ability to serve as intermediates in the production of complex molecules, particularly in the fields of pharmaceuticals and agrochemicals.
  • Flavors and Fragrances: Some lactones are noted for their pleasant aromas, and although 5-phenyltetrahydrofuran-2-one is less commonly discussed, it has the potential to contribute to flavor and fragrance formulations.
  • Research Potential: Ongoing research into this compound could uncover novel biological activities, making it a candidate for the development of new drugs or the study of biochemical processes.
  • Chemical Behavior: It can participate in a variety of chemical reactions, including nucleophilic substitutions and ring-opening reactions, which are fundamental to synthetic strategies in organic chemistry.

In summary, 5-phenyltetrahydrofuran-2-one is not just a simple compound; it embodies a wealth of research possibilities and commercial applications. Its exploration can lead to further insights into its behavior, properties, and potential uses in various fields, demonstrating the importance of studying even the lesser-known compounds.

Synonyms
1008-76-0
gamma-Phenyl-gamma-butyrolactone
5-phenyloxolan-2-one
5-Phenyldihydrofuran-2(3H)-one
4-Phenylbutanolide
4-Phenylbutyrolactone
2(3H)-Furanone, dihydro-5-phenyl-
4-Phenyl-4-butanolide
5-Phenyltetrahydrofuran-2-one
NSC 24259
4-Phenyl-4-hydroxybutanoic acid lactone
NSC 48048
2(3H)-FURANONE, 4,5-DIHYDRO-5-PHENYL-
4,5-Dihydro-5-phenyl-2(3H)-furanone
MFCD00005398
.gamma.-Phenyl-.gamma.-butyrolactone
.gamma.-Phenylbutyrolactone
CHEMBL191989
NSC-24259
NSC-48048
|A-Phenyl-|A-butyrolactone
EINECS 213-761-0
BRN 0125169
5-Phenyl-dihydro-furan-2-one
5-phenyloxolane-2-one
gamma-phenyl butyrolactone
4-phenyl-gamma-butyrolactone
MSP7V2HE35
5-17-10-00026 (Beilstein Handbook Reference)
SCHEMBL982856
ghl.PD_Mitscher_leg0.1063
AEUULUMEYIPECD-UHFFFAOYSA-
5-Phenyldihydro-2(3H)-furanone
DTXSID50870831
dihydro-5-phenyl-2(3h)-furanone
NSC24259
NSC48048
5-Phenyldihydro-2(3H)-furanone #
gamma -Phenyl- gamma -butyrolactone
BBL104384
BDBM50168005
STL558654
AKOS005216508
AKOS017344739
gamma-Phenyl-gamma-butyrolactone, 99%
CS-0214976
NS00042528
P1321
D92106
EN300-210214
InChI=1/C10H10O2/c11-10-7-6-9(12-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2