5-(Trifluoromethyl)-3H-1,3-benzoxazol-2-one

Interesting Facts about 5-(Trifluoromethyl)-3H-1,3-benzoxazol-2-one

5-(Trifluoromethyl)-3H-1,3-benzoxazol-2-one, often referred to as a benzoxazole derivative, is a fascinating chemical compound with numerous applications in research and industry. Here are some interesting aspects:

• Unique Structure: The incorporation of the trifluoromethyl group (–CF₃) enhances the lipophilicity and metabolic stability of the compound, making it valuable in medicinal chemistry.
• Fluorinated Compound: Fluorinated compounds like this one are known for their unique reactivity and solubility properties, making them useful in various chemical reactions.
• Biological Activity: Benzoxazole derivatives are noted for their pharmacological properties, showing promise as antibacterial, antifungal, and antiviral agents, thereby being the focus of significant drug discovery research.
• Electron-Deficient Character: The presence of the electron-withdrawing trifluoromethyl group contributes to the compound's ability to engage in electrophilic substitution reactions, a key reaction in organic synthesis.

As quoted by chemist Dr. Anna Low, "Understanding the structure-function relationship of fluorinated compounds opens new avenues for drug development." This highlights the ongoing interest in such compounds in the scientific community.

Beyond its chemical properties, this compound serves as an excellent example of how modifications in molecular structure—including simple substitutions—can lead to profound changes in reactivity and biological activity, making it a subject of ongoing interest in chemical research.