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Clotiazepam

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Identification
Molecular formula
C16H15ClN2OS
CAS number
33671-46-4
IUPAC name
5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one
State
State
Clotiazepam is in a solid state at room temperature. It is typically provided in a crystalline form for medicinal purposes.
Melting point (Celsius)
198.00
Melting point (Kelvin)
471.00
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
353.82g/mol
Molar mass
353.8230g/mol
Density
1.2700g/cm3
Appearence

Clotiazepam appears as a crystalline solid. It is often seen in its pure, white form when isolated, but can also appear as a solid powder for pharmaceutical use.

Comment on solubility

Solubility of 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one

The solubility behavior of 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one is of particular interest due to its complex structure. Generally, the solubility of such organic compounds can be influenced by several factors:

  • Polarity: Compounds with polar functional groups tend to be more soluble in polar solvents, while non-polar groups enhance solubility in non-polar solvents.
  • Hydrogen Bonding: The presence of hydrogen bond donors or acceptors can significantly increase solubility in protic solvents like water.
  • pH Levels: The solubility can change with pH, especially if the compound can be protonated or deprotonated.
  • Temperature: Increasing temperature can often improve solubility for many solids in liquids.

However, for this specific compound, empirical data on its solubility may be scarce. It is critical to consider:

  • **Experimental Conditions**: Different solvents may yield varying solubility results.
  • **Potential Applications**: Solubility can dictate bioavailability and efficacy in pharmaceutical contexts.
  • **Structure-Solubility Relationship**: Understanding the chemical structure helps predict solubility trends.

In conclusion, while the solubility of 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one can be nuanced, the interplay of physical and chemical properties allows for intriguing exploration into its behavior in various solvents.

Interesting facts

Interesting Facts about 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one

The compound 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one belongs to the benzodiazepine family, which is renowned for its pharmacological effects. Here are some engaging facts about this intriguing compound:

  • Structural Complexity: The unique structure of this compound is indicative of its complex interactions within biological systems. Its intricate arrangement of rings and functional groups allows it to exhibit various chemical properties.
  • Pharmacological Significance: Benzodiazepines are often utilized in therapeutic contexts for their sedative, anxiolytic, and muscle-relaxing properties. The properties of this particular compound suggest potential applications in the treatment of anxiety and other mood disorders.
  • Research Potential: As a member of the isoquinolino class, its structure presents opportunities for ongoing research, particularly in the discovery of new drugs. Scientists explore its reactivity, potential derivatives, and biological activity extensively.
  • Relationship with Neurotransmitters: Compounds in this class generally interact with neurotransmitter systems, particularly the GABAA receptor, which plays a crucial role in inhibitory signaling in the brain.
  • Future Applications: With ongoing advancements in medicinal chemistry, the derivatives of this compound may lead to the development of more effective medications with fewer side effects, potentially reshaping the landscape of psychiatric and neurological therapy.

In summary, the compound 5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one is not just a fascinating structure but also a source of potential benefits in medical science. As research progresses, its place in the pharmacological world may become even more significant.

Synonyms
17656-71-2
6,7,9,10-Tetrahydro-5,10,10-trimethyl-5H-isoquino(2,1-d)(1,4)benzodiazepin-6-one
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-5,10,10-trimethyl-
5,10,10-trimethyl-9,14b-dihydro-7H-isoquinolino[2,1-d][1,4]benzodiazepin-6-one
5,9,10,14b-Tetrahydro-5,10,10-trimethylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
DTXSID40938813
5,10,10-Trimethyl-5,9,10,14b-tetrahydroisoquinolino[2,1-d][1,4]benzodiazepin-6(7H)-one