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Leukotriene B4

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Identification
Molecular formula
C20H32O4
CAS number
71160-24-2
IUPAC name
5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
State
State

At room temperature, Leukotriene B4 is typically in a liquid state, given its relatively low melting point.

Melting point (Celsius)
-40.00
Melting point (Kelvin)
233.15
Boiling point (Celsius)
408.00
Boiling point (Kelvin)
681.15
General information
Molecular weight
336.47g/mol
Molar mass
336.4690g/mol
Density
1.0200g/cm3
Appearence

Leukotriene B4 is typically a colorless to pale yellow liquid. It is usually not isolated or observed directly due to its biological activity, but in its pure form, it would be a clear, oily liquid.

Comment on solubility

Solubility of 5,12-Dihydroxyicosa-6,8,10,14-tetraenoic Acid

5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid (C20H32O4), often referred to as a fatty acid, exhibits unique solubility properties that are crucial for understanding its biological and chemical behavior.

Key Points on Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups significantly influences solubility. This compound has two such groups, which can form hydrogen bonds with water, enhancing its solubility in polar solvents.
  • Hydrophobic Regions: The long hydrocarbon chain contributes to hydrophobic character, suggesting limited solubility in water while providing solubility in non-polar organic solvents.
  • Solvent Interaction: It is more soluble in organic solvents such as ethanol and acetone compared to water, due to the balance between its hydrophilic hydroxyl groups and hydrophobic hydrocarbon tail.
  • Biological Relevance: Understanding its solubility is vital for applications in biochemistry and pharmacology, where it may participate in complex formations with lipids and proteins.

In summary, while 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid demonstrates a notable degree of solubility in polar environments due to its hydroxyl groups, the overarching influence of its hydrophobic components leads to greater solubility in non-polar conditions. This dual characteristic is essential for its functionality in various chemical and biological contexts.

Interesting facts

Interesting Facts about 5,12-Dihydroxyicosa-6,8,10,14-tetraenoic Acid

5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid, often referred to simply as a member of the eicosanoid family, has garnered attention in various fields of biological and medical research. Below are some fascinating aspects of this compound:

  • Role in Inflammation: Eicosanoids, which include compounds like 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid, play a critical role in inflammatory processes within the body. They can function as signaling molecules that modulate inflammation and immune responses.
  • Structural Characteristics: This compound contains multiple double bonds, which gives it unique chemical properties that enhance its biological activity. The term "dihydroxy" indicates the presence of two hydroxyl groups, contributing to its functionality in biological systems.
  • Potential Therapeutic Uses: Investigations are continuously being conducted regarding the therapeutic potential of eicosanoids. The modulation of bodily functions, particularly regarding inflammatory diseases and cardiovascular health, is a key area of interest.
  • Biological Pathway: This acid is integrated into several enzymatic pathways, often acting as a precursor to other bioactive lipids. This means that understanding its role can unlock insights into broader metabolic pathways.
  • Dietary Sources: Compounds similar to this acid are often derived from the diet, particularly from the consumption of fatty fish and certain plant oils, which are known for their high levels of omega-3 and omega-6 fatty acids.

In the words of notable biochemist, "The intricate dance of eicosanoids in our bodies illustrates the complexity of life itself." This emphasizes the importance of understanding such compounds in the larger context of human health and disease.

Research into compounds like 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid not only strengthens our grasp of biochemical pathways but also opens up new avenues for innovative therapies, showcasing the vibrant interplay of chemistry and medicine.

Synonyms
5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
73151-67-4
12-Epi leukotriene B4
6,8,10,14-Eicosatetraenoicacid, 5,12-dihydroxy-
LTB4;5(S),12(R)-DiHETE
124629-74-9
starbld0003804
DTXSID40860923
DB-055549
DB-056737
5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid
Q2704449
Q41596312