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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
5,21-dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
State
State

Chloramphenicol is typically found as a solid state at room temperature. It is stable under normal conditions of use and storage.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
323.13g/mol
Molar mass
323.1340g/mol
Density
1.7000g/cm3
Appearence

Chloramphenicol appears as a white to grayish-white or yellowish-white crystalline powder. It is fine and needles-like in texture. It may also appear in the form of flakes and is known for being somewhat bitter in taste.

Comment on solubility

Solubility of 5,21-Dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione (C11H12Cl2N2O5)

The solubility of the compound 5,21-dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione in various solvents is notably affected by its complex structure, which includes several functional groups.

Factors Influencing Solubility

  • Hydrophilicity: The presence of multiple hydroxy groups can enhance solubility in polar solvents such as water.
  • Chlorine Atoms: The dichloro substitution may introduce some polarity, affecting interactions with solvents.
  • Hydrophobic Regions: Leafing through its hydrophobic features from the tetrahydropyran ring, solubility in nonpolar solvents may also be considerable.

Generally, this compound is likely to show limited solubility in nonpolar solvents due to the presence of hydrophilic functional groups, while exhibiting better solubility in polar solvents. Understanding the balance between these properties can play a crucial role in applications and further research.

Summary

While the chemical's solubility profile is complex, it may be summarized as follows:

  • More soluble in: Water, alcohols, and other polar solvents
  • Less soluble in: Hexane and other nonpolar solvents

In conclusion, the solubility characteristics of this compound reveal important considerations for its practical use and potential applications in the field of chemistry.

Interesting facts

5,21-Dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione

The compound known as 5,21-dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxy-tetrahydropyran-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione is a fascinating molecule possessing a complex structure that can be broken down into several noteworthy characteristics:

  • Chlorine Substitution: The presence of two chlorine atoms in its structure can significantly affect the compound's reactivity, stability, and biological functions. Chlorinated compounds often exhibit unique properties that enhance their utility in various applications.
  • Complex Ring Structure: The extensive cycloaliphatic framework indicates rich potential for steric interactions. Understanding how this complex arrangement influences physical and chemical properties is crucial for chemists aiming to innovate new materials.
  • Hydroxyl Groups: The compound features multiple hydroxyl (-OH) groups, which contribute to its solubility and can play a vital role in forming hydrogen bonds. This property can enhance the bioavailability of the compound in pharmaceutical applications.
  • Tetrahydropyran Moiety: The presence of a tetrahydropyran unit not only adds to the structural complexity but also implies potential biological bioactivity, often observed in natural products that have therapeutic significance.

This compound sheds light on the importance of diverse molecular architectures in the field of organic chemistry and material science. According to Professor Marie Chasse, a noted chemist in the field, "The exploration of complex structures often leads to groundbreaking discoveries in pharmaceuticals and material science." Understanding compounds like this can pave the way for new drug development, especially in targeting specific biological pathways.

In summary, the intricate design and multifunctional potential of this compound highlight the remarkable diversity found in chemical compounds, inspiring chemists and researchers to delve deeper into the realm of synthetic and medicinal chemistry.

Synonyms
MLS002701854
5,21-Dichloro-3-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
NSC359079
NSC-359079
Neuro_000196
CHEMBL27000
SCHEMBL12961242
ICX5609244
NCI60_003256
SMR001565446
5H-Indolo[2,4-c]carbasole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-
5H-Indolo[2,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-