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Nitrazepam

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Identification
Molecular formula
C12H11F3N3O4
CAS number
80-52-2
IUPAC name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
State
State

At room temperature, nitrazepam is a solid. It is generally stable under regular conditions of storage, handling, and temperature.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
295.67
Boiling point (Kelvin)
568.82
General information
Molecular weight
260.23g/mol
Molar mass
260.2270g/mol
Density
1.4800g/cm3
Appearence

Nitrazepam typically appears as a crystalline powder. It is colorless or white, and is usually odorless. When exposed to air, its consistency remains stable.

Comment on solubility

Solubility of 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione

The solubility characteristics of 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione (C12H11F3N3O4) present a fascinating insight into the dynamics of non-ionic compounds. The unique structure of this compound suggests several key factors influencing its solubility:

  • Polarity: The presence of fluorine atoms contributes to a degree of polarity, which can affect solubility in various solvents.
  • Functional Groups: The nitro group (–NO2) can introduce hydrogen bonding capabilities, potentially enhancing solubility in polar solvents.
  • Hydrophobic Regions: The dimethyl and trifluoromethyl groups create hydrophobic interactions that may limit solubility in highly polar solvents.

In practice, the solubility can vary considerably based on the solvent system employed. For instance, polar solvents such as dimethyl sulfoxide (DMSO) or ethanol may facilitate better solvation due to the ability to engage with both polar and non-polar regions of the molecule. Conversely, less polar solvents may struggle to dissolve this compound effectively due to the significant hydrophobic character introduced by the trifluoromethyl and dimethyl substitutions.

In summary, while 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione exhibits solubility potential, its actual behavior in solution is a complex interplay of molecular interactions that warrant further investigation.

Interesting facts

Interesting Facts About 5,5-Dimethyl-3-[4-Nitro-3-(Trifluoromethyl)Phenyl]Imidazolidine-2,4-Dione

This compound, with its complex structure, belongs to a fascinating class of chemical compounds used in various fields of research and application. Here are some intriguing insights:

  • Pharmaceutical Potential: Compounds like this one often serve as intermediates in the synthesis of pharmaceuticals, particularly in developing drugs that target specific biochemical processes.
  • Innovative Applications: Due to its unique fluorinated structure, this compound may be explored for properties related to both hydrophobicity and lipophilicity, making it interesting for drug development.
  • Environmental Impact: The inclusion of trifluoromethyl groups in its structure hints at potential applications as agrochemicals, affecting both efficacy and environmental persistence.
  • Synthetic Routes: The synthesis of such complex organic molecules often involves innovative synthetic strategies, showcasing the creativity and skill needed in modern organic chemistry.
  • Multi-Functional Roles: The presence of nitro groups can enhance various properties, such as increased reactivity and the ability to engage in further chemical transformations.

In summary, 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione exemplifies the intricate relationships between structure and function in chemistry. As researchers continue to explore such compounds, there is no telling what novel applications may emerge, paving the way for advancements in both medicinal and environmental sciences.

Synonyms
nilutamide
63612-50-0
Anandron
Nilandron
Nilandrone
5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione
Nilutamida
Nilutamidum
RU-23908
Nilutamidum [Latin]
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
RU 23908
5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin
RU 23908-10
NSC-758683
BRN 0841906
CHEBI:7573
UNII-51G6I8B902
2,4-Imidazolidinedione,5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
Nilandron;RU 23908
MFCD00864670
51G6I8B902
CHEMBL1274
1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazolidine-2,5-dione
5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione
2,4-IMIDAZOLIDINEDIONE, 5,5-DIMETHYL-3-(4-NITRO-3-(TRIFLUOROMETHYL)PHENYL)-
DTXSID3034165
Nilutamida [Spanish]
5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Nilutamidum (Latin)
NSC 758683
NCGC00015754-08
CAS-63612-50-0
NILUTAMIDE (MART.)
NILUTAMIDE [MART.]
NILUTAMIDE (USP-RS)
NILUTAMIDE [USP-RS]
C12H10F3N3O4
DTXCID1014165
NILUTAMIDE (EP MONOGRAPH)
NILUTAMIDE [EP MONOGRAPH]
Nilutamide [USAN:INN:BAN]
NILUTAMIDE (USP MONOGRAPH)
NILUTAMIDE [USP MONOGRAPH]
5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)-phenyl)imidazolidine-2,4-dione
Nilandron (TN)
SR-01000076034
Nilutamide (USAN/INN)
Nilutamide, solid
2,4-Imidazolidinedione, 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-
Nilutamide; 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
Nilutamide (Standard)
Spectrum_001625
Tocris-1759
NILUTAMIDE [MI]
SpecPlus_000902
NILUTAMIDE [INN]
Prestwick0_000928
Prestwick1_000928
Prestwick2_000928
Prestwick3_000928
Spectrum2_001973
Spectrum3_001633
Spectrum4_000600
Spectrum5_001512
Lopac-N-8534
NILUTAMIDE [USAN]
NILUTAMIDE [VANDF]
N 8534
NILUTAMIDE [WHO-DD]
BIDD:PXR0177
Lopac0_000879
SCHEMBL12670
BSPBio_000836
BSPBio_003325
KBioGR_001100
KBioSS_002105
MLS002154066
BIDD:GT0683
DivK1c_006998
SPECTRUM1504152
SPBio_002125
SPBio_003015
BPBio1_000920
GTPL2864
Nilutamide - Bio-X trade mark
NILUTAMIDE [ORANGE BOOK]
KBio1_001942
KBio2_002105
KBio2_004673
KBio2_007241
KBio3_002545
L02BB02
BCPP000148
HMS1570J18
HMS1922F03
HMS2093A10
HMS2097J18
HMS2230E03
HMS3262P19
HMS3268C18
HMS3369I02
HMS3414N15
HMS3678N13
HMS3714J18
Pharmakon1600-01504152
BCP26617
Tox21 110213
Tox21_110213
Tox21_301589
Tox21_500879
BDBM50135912
CCG-39427
HY-13702R
NSC684588
NSC758683
s4836
STK633161
AKOS005565152
AKOS025147305
Tox21_110213_1
AC-5260
BCP9000990
DB00665
FN26218
LP00879
SB19036
SDCCGSBI-0050854.P004
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-1,3-diazolidine-2,4-dione
NCGC00015754-01
NCGC00015754-02
NCGC00015754-03
NCGC00015754-04
NCGC00015754-05
NCGC00015754-06
NCGC00015754-07
NCGC00015754-09
NCGC00015754-10
NCGC00015754-11
NCGC00015754-12
NCGC00015754-15
NCGC00015754-16
NCGC00015754-22
NCGC00025280-01
NCGC00025280-02
NCGC00025280-03
NCGC00025280-04
NCGC00025280-05
NCGC00025280-06
NCGC00025280-07
NCGC00025280-08
NCGC00255271-01
NCGC00261564-01
AS-14123
BN166184
HY-13702
SMR001233381
SBI-0050854.P003
AB00053180
CS-0007719
EU-0100879
N1212
NS00015500
C08164
D00965
EN300-316458
AB00053180_07
L000759
Q3877030
RU-23908;RU 23908;RU23908
SR-01000076034-1
SR-01000076034-3
SR-01000076034-5
SR-01000076034-6
SR-01000076034-9
BRD-K23566484-001-05-2
BRD-K23566484-001-09-4
BRD-K23566484-001-14-4
BRD-K23566484-001-15-1
Z2242164525
Nilutamide, European Pharmacopoeia (EP) Reference Standard
1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazoline-3,5-dione
1-(3'-trifluoromethyl-4'-nitrophenyl)4,4-dimethyl-imidazoline-2,5-dione
1-(3'-trifluoromethyl-4'nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
1-(3'trifluoromethyl-4'-nitropheyl)-4,4-dimethyl-imidazoline-2,5-dione
1-(3-'trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione
1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl-imidazolidine-2,5-dione
1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl-imidazoline-2,5-dione
1-(3-trifluoromethyl-4-nitrophenyl)-4,4-dimethyl-imidazoline-2,5-dione
5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-imidazolidine-2,4-dione
5,5-DIMETHYL-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-4-NITRO-M-TOLYL)HYDANTOIN
5,5-Dimethyl-3-(4-nitro-3-(trifluoro-methyl)phenyl)-2,4-imidazolidinedione
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-imidazolidine-2,4-dione
5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedion;1-3-Trifluoromethyl-4-nitrophenyl)-4,4-dimethylimidazoline- 2,5-dione;Anandron
5,5-Dimethyl-3-4-nitro-3-(trifluoromethyl)phenyl-2,4-imidazolidinedion;1-3-Trifluoromethyl-4-nitrophenyl)-4,4-dimethylimidazoline- 2 ,5-dione;Anandron