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Nefopam

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Identification
Molecular formula
C17H19NO3
CAS number
13669-70-0
IUPAC name
5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one
State
State

At room temperature, nefopam is typically a solid. It maintains its solid crystalline form under standard conditions (20-25°C and 1 atm pressure) and does not emit any significant fumes or volatile compounds unless exposed to higher temperatures that approach its boiling or decomposition points.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
295.15
Boiling point (Kelvin)
568.30
General information
Molecular weight
303.35g/mol
Molar mass
307.3890g/mol
Density
1.1860g/cm3
Appearence

Nefopam typically appears as a white crystalline powder. Its crystalline nature is due to the highly organized molecular structure it forms in the solid state. The compound is known for its purity and is devoid of any color or strong odor in its stand-alone chemical form.

Comment on solubility

Solubility of 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one

The solubility of the compound 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one can be assessed based on its chemical structure and properties. Being a complex organocyclic molecule, its solubility characteristics may exhibit variations depending on the solvent used.

Factors Influencing Solubility

The solubility of this compound can be influenced by the following factors:

  • Polarity: The presence of polar groups can enhance solubility in polar solvents.
  • Molecular Interactions: Hydrogen bonding capability can influence stability and solubility in various solutions.
  • Molecular Size: Larger molecules may exhibit lower solubility due to steric hindrance.

Typical Solvents

This compound may demonstrate different solubility behavior in:

  • Polar solvents, such as water or alcohols, which could potentially dissolve the compound due to favorable interactions.
  • Non-polar solvents, like hydrocarbons, where it may have limited solubility due to a lack of favorable interactions.

Conclusion

In summary, while direct data on the solubility of 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one in specific solvents may not be readily available, understanding the molecular characteristics and applying general principles of solubility can guide researchers in exploring its behavior in various solutions. Clarifying these interactions is crucial for applications in pharmaceuticals and material science.

Interesting facts

Interesting Facts About 5,5-Diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one

This fascinating compound belongs to a class of chemicals known as dioxolanes, which are characterized by their unique structural features and diverse reactivity. Here are some intriguing points about 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one:

  • Diverse Applications: The presence of both dioxolane and piperidine groups in its structure indicates that this compound may have applications in the realm of medicinal chemistry, particularly in the development of pharmacologically active agents.
  • Structural Diversity: The incorporation of the diphenyl moiety in the molecule enhances its steric and electronic properties, which can influence the compound's behavior in chemical reactions and interactions with biological systems.
  • Reactivity: Dioxolanes are known for their electrophilic character, making compounds like this one useful in organic synthesis—for example, as intermediates in the creation of more complex molecules.
  • Potential Therapeutic Benefits: Compounds containing piperidine rings are often investigated for their potential analgesic, anti-inflammatory, and psychoactive properties. This suggests that 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one could lead to interesting new pharmacological research.
  • Interdisciplinary Connections: The study of such compounds bridges organic chemistry and medicinal chemistry, offering students and researchers the chance to explore multiple facets of the current scientific landscape.

In summary, 5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one serves as a perfect example of how complex molecular structures can lead to a variety of applications in drug discovery and materials science. With ongoing research in this area, the potential for novel discoveries remains vast.

Synonyms
Pipoxolan
23744-24-3
493GZJ5T6I
1,3-Dioxolan-4-one, 5,5-diphenyl-2-(2-(1-piperidinyl)ethyl)-
5,5-diphenyl-2-(beta-N-piperidinoethyl)-1,3-dioxolan-4-one
5,5-diphenyl-2-(2-piperidin-1-ylethyl)-1,3-dioxolan-4-one
Pipoxolan (INN)
PIPOXOLAN [INN]
Rowapraxin (TN)
5,5-Diphenyl-2-(2-piperidinoethyl)-1,3-dioxolan-4-one
Pipossolano
Pipoxolanum
Pipoxolanum [INN-Latin]
Pipossolano [DCIT]
Pipoxolan [INN:BAN]
UNII-493GZJ5T6I
PIPOXOLAN [MART.]
PIPOXOLAN [WHO-DD]
SCHEMBL669035
orb1739819
CHEMBL2110645
DTXSID20865113
CHEBI:135483
DXSUDONPFZKWOO-UHFFFAOYSA-N
BCP20276
BR 18 pound>>BR18 pound>>BR-18
NS00008114
D07369
Q27259212
1,3-DIOXOLAN-4-ONE, 5,5-DIPHENYL-2-(2-PIPERIDINOETHYL)-
5,5-DIPHENYL-2-(2'-PIPERIDINOETHYL)-1,3-DIOXOLAN-4-ONE
5,5-Diphenyl-2-[2-(1-piperidinyl)ethyl]-1,3-dioxolan-4-one #
5,5-diphenyl-2-[2-(piperidin-1-yl)ethyl]-1,3-dioxolan-4-one
(+/-)-5,5-DIPHENYL-2-(2-PIPERIDINOETHYL)-1,3-DIOXOLAN-4-ONE
5,5-DIPHENYL-2-(2-(1-PIPERIDINYL)ETHYL)-1,3-DIOXOLAN-4-ONE
5,5-diphenyl-2-[2-(1-piperidyl)ethyl]-1,3-dioxolan-4-one hydrochloride
27769-60-4