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5,6-Dichloro-2-aminobenzothiazole

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Identification
Molecular formula
C7H4Cl2N2S
CAS number
27318-90-7
IUPAC name
5,6-dichloro-1,3-benzothiazol-2-amine
State
State
At room temperature, 5,6-Dichloro-2-aminobenzothiazole is in a solid state. It is commonly found as a powder and is used in various chemical synthesis applications.
Melting point (Celsius)
150.00
Melting point (Kelvin)
423.00
Boiling point (Celsius)
313.50
Boiling point (Kelvin)
586.65
General information
Molecular weight
221.09g/mol
Molar mass
221.0580g/mol
Density
1.7300g/cm3
Appearence
5,6-Dichloro-2-aminobenzothiazole typically appears as a slightly off-white crystalline powder. The powder is stable under standard conditions and does not have any significant or distinct odor.
Comment on solubility

Solubility of 5,6-Dichloro-1,3-benzothiazol-2-amine

The solubility of 5,6-dichloro-1,3-benzothiazol-2-amine is an essential aspect to consider, particularly in various chemical and biological applications. This compound exhibits some interesting solubility characteristics:

  • Solvent Compatibility: It tends to be soluble in polar organic solvents such as DMSO (dimethyl sulfoxide) and DMF (dimethylformamide).
  • Water Solubility: Water solubility is limited, making it less effective for reactions that require aqueous environments.
  • Effect of Temperature: Like many organic compounds, its solubility may increase with temperature, which is a critical factor when considering dissolution processes.
  • Functional Group Influence: The presence of the amine group (-NH2) can enhance interactions with polar solvents, while the dichloro and benzothiazole moieties can create a balance between hydrophilicity and hydrophobicity.

In summary, the solubility of 5,6-dichloro-1,3-benzothiazol-2-amine is predominantly influenced by its chemical structure and the choice of solvents used. Understanding these properties is crucial for optimizing its use in synthetic and analytical chemistry applications.

Interesting facts

Interesting Facts about 5,6-Dichloro-1,3-benzothiazol-2-amine

The compound 5,6-dichloro-1,3-benzothiazol-2-amine, often referred to for its intricate benzothiazole structure, holds significant importance in the realm of organic chemistry and pharmaceuticals. Here are some fascinating insights about this compound:

  • Structure and Function: The benzothiazole moiety is a well-known chemical scaffold in medicinal chemistry. The presence of chlorine atoms enhances the compound's reactivity and can influence its biological activity.
  • Biological Activity: Compounds containing benzothiazole derivatives are frequently investigated for their potential therapeutic applications. They have been studied for anti-cancer, anti-inflammatory, and antimicrobial properties.
  • Synthesis Techniques: The synthesis of 5,6-dichloro-1,3-benzothiazol-2-amine can involve various synthetic pathways, often employing reactions that form crucial carbon-nitrogen bonds. Techniques such as cyclization and halogenation are commonly used.
  • Environmental Impact: The chlorinated nature of this compound raises discussions regarding its environmental fate, particularly around its biodegradability and potential to bioaccumulate in living organisms.
  • Research Prospects: The study of 5,6-dichloro-1,3-benzothiazol-2-amine opens doors to further exploration in the design of new ligands for targeting specific proteins in various diseases.

As highlighted by many researchers, "The chemistry of benzothiazoles continues to evolve, paving the way for innovative therapeutic solutions." This underscores the compound’s potential role in drug development and highlights its significance within the broader scientific landscape.

In summary, 5,6-dichloro-1,3-benzothiazol-2-amine is not just a compound of theoretical interest but also a player in real-world applications, particularly in the field of pharmaceuticals, making it a noteworthy subject in the study of chemical compounds.

Synonyms
24072-75-1
2-Amino-5,6-dichlorobenzothiazole
5,6-DICHLORO-2-BENZOTHIAZOLAMINE
2-Benzothiazolamine, 5,6-dichloro-
CCRIS 742
5,6-Dichlorobenzothiazol-2-amine
EINECS 246-006-9
Z7P3YF9P8H
Benzothiazole, 2-amino-5,6-dichloro-
DTXSID5024477
5,6-dichloro-2-aminobenzothiazole
5,6-dichloro-1,3-benzothiazol-2-ylamine
DICHLORO-2-BENZOTHIAZOLAMINE, 5,6-
RefChem:527994
DTXCID104477
631-598-7
5,6-Dichlorobenzo[d]thiazol-2-amine
5,6-Dichloro-1,3-benzothiazol-2-amine
MFCD00053558
UNII-Z7P3YF9P8H
SCHEMBL2899732
SCHEMBL29462442
STR04172
2-Amino-5,6-dichloro-benzothiazole
AKOS008901401
AC-27291
SY074388
5,6-Dichloro-1,3-benzothiazol-2-amine #
DB-046337
CS-0096145
NS00003279
S12410
150A270