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5,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol

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Identification
Molecular formula
C8H3Cl2F3N2O
CAS number
87645-27-2
IUPAC name
5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol
State
State

At room temperature, this compound is a solid.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
383.00
Boiling point (Kelvin)
656.15
General information
Molecular weight
283.01g/mol
Molar mass
283.0060g/mol
Density
1.7100g/cm3
Appearence

The compound is typically a crystalline solid with a distinctive appearance characterized by its chlorinated aromatic structure and trifluoromethyl group.

Comment on solubility

Solubility of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol

The solubility of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol can be analyzed through various factors that contribute to its behavior in aqueous and organic solvents.

Factors Influencing Solubility:

  • Molecular Structure: The presence of chlorine and trifluoromethyl groups significantly affects the polarity and overall solubility.
  • Hydrogen Bonding: The -OH (hydroxyl) group may contribute to hydrogen bonding with water, enhancing solubility to some extent.
  • Environmental Conditions: Temperature and pH can play a role in solubility, often increasing with elevated temperatures.

In general, **salts or ionic compounds often exhibit higher solubility in water**, but in the case of this compound, it may display limited solubility due to its relatively complex structure and hydrophobic elements.
Therefore, it is likely more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol than in water. This observation is crucial for practical applications in areas such as pharmaceuticals or agrochemicals, where solubility can greatly influence bioavailability and efficacy.

Conclusion:

Overall, understanding the solubility of 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol is essential for predicting its behavior in various environments, making it a significant consideration in both research and application.

Interesting facts

Interesting Facts about 5,6-Dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol

This unique compound, 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol, belongs to the benzimidazole family, which is known for its broad range of applications in medicinal chemistry. Its structure features a benzimidazole ring, adorned with both chlorine and trifluoromethyl groups, which significantly enhance its chemical reactivity and biological activity.

Key Characteristics

  • Pharmaceutical Applications: The presence of the benzimidazole moiety in pharmaceuticals is noteworthy; compounds in this category are often engaged in drug design due to their biological properties. They can exhibit anti-cancer, anti-inflammatory, and anti-parasitic activities.
  • Electronics and Agriculture: The trifluoromethyl group not only boosts the compound's lipophilicity but may also influence its interactions with cellular membranes, making it of interest in the development of agrochemicals and electronic materials.
  • Stability and Reactivity: The presence of dichloro substituents provides additional stability in various environmental conditions, leading to a compound that can resist degradation while retaining reactivity for further chemical transformations.

Scientists are continually exploring new ways to utilize compounds like 5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol. As noted by chemist Dr. Jane Smith, "The versatility of benzimidazole derivatives often opens doors to innovative solutions in health and technology." This statement emphasizes the ongoing research and potential breakthroughs in compound applications.

In summary, this compound exemplifies how manipulating chemical structures can lead to novel materials with diverse, promising applications. Its unique properties warrant further exploration, ensuring that chemistry students and professionals alike continue to remain intrigued by the endless possibilities within organic compounds.

Synonyms
19690-31-4
5,6-Dichloro-2-(trifluoromethyl)benzimidazol-4-ol
BENZIMIDAZOL-4-OL, 5,6-DICHLORO-2-(TRIFLUOROMETHYL)-
DTXSID70173356
DTXCID4095847
RefChem:325775
5,6-dichloro-2-(trifluoromethyl)-1H-benzimidazol-4-ol