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5,6-Dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C8H2Cl2F3N3O2
CAS number
94413-64-6
IUPAC name
5,6-dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole
State
State
This compound is generally found as a solid at room temperature, typically in the form of a yellow crystalline powder.
Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
337.00
Boiling point (Kelvin)
610.15
General information
Molecular weight
317.00g/mol
Molar mass
316.9990g/mol
Density
1.7800g/cm3
Appearence

5,6-Dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole usually appears as a yellow crystalline solid due to the presence of the nitro group, which often contributes to its coloration.

Comment on solubility

Solubility of 5,6-dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 5,6-dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a multifaceted aspect that deserves attention. Generally speaking:

  • The compound exhibits limited solubility in polar solvents due to its hydrophobic aromatic structure.
  • It tends to be more soluble in non-polar solvents, which can help facilitate its dissolution.
  • Factors such as temperature and pH can also significantly influence the solubility of this compound.

Some key considerations regarding its solubility include:

  1. Hydrophobic Groups: The presence of a trifluoromethyl group increases hydrophobic interactions, reducing solubility in water.
  2. Substituents: The two chloro and nitro substituents can impart varying electronic properties, which may complicate solubility profiles.
  3. Interactions: Potential interactions with solvents (like hydrogen bonding or van der Waals forces) can play a crucial role in determining solubility.

In summary, while 5,6-dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is largely insoluble in water, its solubility can improve in organic solvents. Understanding these factors is critical for practical applications in pharmaceuticals and agrochemicals.

Interesting facts

Interesting Facts about 5,6-Dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole

5,6-Dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole is a fascinating compound that belongs to the benzimidazole family, known for its diverse applications in pharmaceuticals and agrochemicals. Below are some intriguing aspects of this compound:

  • Pharmaceutical Potential: Compounds of the benzimidazole class are significant in medicinal chemistry, particularly for their roles as anti-parasitic agents.
  • Structural Features: The presence of multiple halogen substituents, such as Cl (chlorine) and F (fluorine), enhances the compound's chemical stability and biological activity.
  • Inhibition Mechanisms: Many benzimidazoles act by disrupting microtubule formation, which is crucial for cell division, indicating their potential in cancer research.
  • Environmental Impact: This compound, given its structure, may also be studied for its environmental interactions, particularly concerning its persistence and mobility in different ecosystems.
  • Research Implications: Ongoing research continues to explore derivatives of benzimidazole for improved efficacy and reduced side effects in therapeutic applications.

Overall, 5,6-dichloro-4-nitro-2-(trifluoromethyl)-1H-benzimidazole exemplifies the complexity and utility of modern chemical compounds. Its unique structure allows for a variety of studies in both biological and environmental science, illustrating the ever-evolving landscape of chemical research.

Synonyms
BENZIMIDAZOLE, 5,6-DICHLORO-4-NITRO-2-(TRIFLUOROMETHYL)-
6609-41-2
5,6-Dichloro-4-nitro-2-(trifluoromethyl)benzimidazole
DTXSID00216285
DTXCID00138776
SCHEMBL8855505
DCCVVWRWIMIAHK-UHFFFAOYSA-N