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Methiothepin

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Identification
Molecular formula
C24H31N3O3
CAS number
73843-90-0
IUPAC name
5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole
State
State

At room temperature, Methiothepin is generally found in a solid state. It typically exists as a white to off-white crystalline powder, maintaining its structure under standard conditions. Its physical state can be attributed to the compound's intermolecular interactions and chemical composition, which allow it to maintain a stable form at ambient temperatures.

Melting point (Celsius)
101.00
Melting point (Kelvin)
374.15
Boiling point (Celsius)
548.12
Boiling point (Kelvin)
821.27
General information
Molecular weight
407.53g/mol
Molar mass
407.5400g/mol
Density
1.2200g/cm3
Appearence

Methiothepin typically appears as a white to off-white crystalline powder. It may also be encountered in solid form as a crystalline structure. In some instances, the compound may also display a slight yellowish tint, but it remains primarily white in coloration.

Comment on solubility

Solubility of 5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole

The solubility of 5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole can be influenced by various factors, making it an interesting compound to study.

Factors Influencing Solubility

  • Polarity: The presence of methoxy groups can enhance the polarity of the compound, thereby influencing its solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents can significantly impact solubility, particularly in protic solvents.
  • pH Levels: The solubility may vary with changes in pH, especially if the compound can exist in different protonation states.

Common Solvents

This compound is likely to have enhanced solubility in:

  • Dimethyl sulfoxide (DMSO)
  • Alcohols (e.g. ethanol, methanol)
  • Chloroform

General Observations

In terms of solubility in water, one might expect the compound to have limited solubility due to its overall structure, which may render it more soluble in organic solvents as opposed to polar aqueous mediums. Ultimately, the solubility profile of 5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole is a reflection of its unique chemical architecture, and empirical testing is recommended to ascertain precise solubility parameters.

Interesting facts

Interesting Facts about 5,6-Dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole

This intriguing compound belongs to the family of indoles, which are known for their diverse biological activities and aromatic nature. Here are some captivating points about it:

  • Complex Structure: The compound features a highly intricate molecular arrangement, incorporating both piperazine and methoxy groups, which are known to enhance biological activity and solubility in medicinal chemistry.
  • Biological Significance: Indole derivatives, such as this one, often exhibit a variety of pharmacological properties. They are being researched for their potential in treating conditions ranging from depression to neurodegenerative diseases.
  • Unique Modifications: The presence of methoxy groups contributes to electronic and steric effects, potentially modulating the compound's interaction with biological receptors. This can lead to optimized pharmacological profiles.
  • Research Potential: Ongoing studies suggest that compounds like this one may act on pathways relevant to psychiatric disorders, indicating a promising avenue for drug development.
  • Global Impact: The exploration of such complex compounds often bridges various fields, including medicinal chemistry, pharmacology, and even synthetic organic chemistry, demonstrating the interdisciplinary nature of modern science.

In summary, the intriguing structure and potential applications of 5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole make it a fascinating subject of study in the world of chemistry. As research progresses, this compound could lead to significant advancements in therapeutic agents.

Synonyms
MILIPERTINE
24360-55-2
Milipertinum
Milipertina
Win 18,935
WX1V67H28T
WIN-18935
DTXSID00179104
5,6-dimethoxy-3-(2-(4-o-methoxyphenyl-1-piperazinyl)-ethyl)-2-methylindole hemitar trate
RefChem:925894
DTXCID90101595
5,6-dimethoxy-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-1H-indole
5,6-Dimethoxy-3-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-2-methylindole
1H-Indole, 5,6-dimethoxy-3-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-2-methyl-
Milipertine [USAN:INN]
Milipertinum [INN-Latin]
Milipertina [INN-Spanish]
UNII-WX1V67H28T
Win 18935
5,6-Dimethoxy-3-[2-[4-(O-methoxyphenyl)-1-piperazinyl]ethyl]-2-methylindole
MILIPERTINE [INN]
Milipertine (USAN/INN)
MILIPERTINE [USAN]
SCHEMBL122335
CHEMBL2105252
SCHEMBL29710920
NS00126789
D02673
Q27292981