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5,6-Dimethyl-2-(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C10H9F3N2
CAS number
60460-68-4
IUPAC name
5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole
State
State

At room temperature, 5,6-Dimethyl-2-(trifluoromethyl)-1H-benzimidazole is a solid. It is generally stable under normal conditions and does not readily evaporate or change state without application of significant heat.

Melting point (Celsius)
126.50
Melting point (Kelvin)
399.65
Boiling point (Celsius)
314.30
Boiling point (Kelvin)
587.45
General information
Molecular weight
230.19g/mol
Molar mass
230.2200g/mol
Density
1.3421g/cm3
Appearence

5,6-Dimethyl-2-(trifluoromethyl)-1H-benzimidazole typically appears as a white to off-white crystalline solid. Its color and form can vary slightly based on the level of purity and processing methods.

Comment on solubility

Solubility of 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole

The solubility of 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole can exhibit interesting characteristics due to its unique molecular structure. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar Solvents: This compound contains both hydrophobic (nonpolar) regions and polar functional groups, making its solubility variable. Generally, it may be more soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO) compared to water.
  • Temperature Influence: Changes in temperature can significantly affect solubility. As the temperature increases, so does the kinetic energy of the molecules, often leading to enhanced solubility in various solvents.
  • pH Sensitivity: Depending on the pH of the solvent, the solubility may vary, especially if protonation or deprotonation occurs in the presence of acids or bases.
  • Crystallization Behavior: The structural properties of 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole may also lead to specific crystallization patterns, influencing how it dissolves in a solvent.

In summary, while the precise solubility characteristics of 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole can depend on various factors, it is generally expected to have limited solubility in water and greater solubility in nonpolar organic solvents. Understanding these nuances can be beneficial in practical applications involving this compound.

Interesting facts

Interesting Facts about 5,6-Dimethyl-2-(trifluoromethyl)-1H-benzimidazole

The fascinating compound 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole is a member of the benzimidazole family, known for its diverse chemical and biological properties. Here are some notable facts about this intriguing compound:

  • Pharmaceutical Relevance: Compounds in the benzimidazole class have been widely studied for their biological activity. Many derivatives show promise as anti-cancer, anti-inflammatory, and anti-microbial agents.
  • Fluorine Influence: The presence of the trifluoromethyl group is significant as it can enhance the strength and stability of the compound, making it more effective in biological applications.
  • Structural Features: The dimethyl substitutions at positions 5 and 6 of the benzimidazole ring often contribute to the compound's lipophilicity, affecting its absorption and distribution in biological systems.
  • Synthesis Versatility: The synthetic pathways for creating such compounds often allow for modifications that can lead to a library of varied derivatives, useful in drug discovery.

For chemistry enthusiasts, the study of benzimidazole derivatives like this one emphasizes the importance of molecular structure in determining function. The combination of heteroatoms and functional groups can lead to unique properties. Understanding these compounds provides essential insights into the field of medicinal chemistry.

As the renowned scientist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." This rings true in the world of compound synthesis where even slight changes can yield completely different behaviors and activities. The exploration of compounds such as 5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole continually inspires the quest for innovative therapeutic solutions.

Synonyms
5,6-Dimethyl-2-trifluoromethylbenzimidazole
634-033-2
1799-79-7
5,6-dimethyl-2-(trifluoromethyl)-1H-benzimidazole
5,6-dimethyl-2-(trifluoromethyl)-1H-benzo[d]imidazole
BENZIMIDAZOLE, 5,6-DIMETHYL-2-TRIFLUOROMETHYL-
1H-Benzimidazole, 5,6-dimethyl-2-(trifluoromethyl)-
H8PX999RE7
NSC-97019
2-(Trifluoromethyl)-5,6-dimethyl-1H-benzimidazole
NSC 97019
BRN 0613679
NSC97019
MFCD00022676
UNII-H8PX999RE7
5-23-06-00505 (Beilstein Handbook Reference)
SCHEMBL7807160
CHEMBL1946481
DTXSID30170881
AKOS010204019
WLN: T56 BM DNJ CXFFF G1 H1
Benzimidazole,6-dimethyl-2-trifluoromethyl-
CS-0078989
1H-Benzimidazole,6-dimethyl-2-(trifluoromethyl)-
5,6-Dimethyl-2-trifluoromethyl-1H-benzoimidazole