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Galantamine Hydrobromide

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Identification
Molecular formula
C17H22BrNO3
CAS number
1953-04-4
IUPAC name
5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-isopropyl-3-methoxy-butanoate
State
State

At room temperature, Galantamine hydrobromide remains in a solid state, typically as a crystalline powder.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
368.27g/mol
Molar mass
368.2690g/mol
Density
1.3598g/cm3
Appearence

Galantamine hydrobromide appears as a white to off-white crystalline powder. It is soluble in water and methanol but less soluble in organic solvents such as acetone and ethyl acetate.

Comment on solubility

Solubility of 5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-isopropyl-3-methoxy-butanoate

The solubility of the compound 5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-isopropyl-3-methoxy-butanoate can be influenced by several factors. Understanding its solubility characteristics is crucial for applications in pharmacology, chemistry, and biochemistry. Here are some key points to consider:

  • Polarity: This compound features multiple functional groups that can affect its overall polarity. Generally, molecules that contain hydroxyl (-OH) and methoxy (-OCH₃) groups tend to exhibit greater solubility in polar solvents such as water.
  • Solvent Interaction: It is expected to show a higher solubility in polar solvents due to the formation of hydrogen bonds between the solvent and the functional groups present in the molecule.
  • Temperature: Like many organic compounds, solubility can increase with temperature. This is particularly important in the context of dissolution processes where higher temperatures may lead to enhanced solubility.
  • pH Considerations: Solutions of this compound may also exhibit different solubility behaviors at varying pH levels, particularly because it contains acidic and basic functionalities.
  • Concentration: The concentration of the solution can influence solubility, especially if the compound exhibits characteristics such as supersaturation.

In summary, the solubility of 5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-isopropyl-3-methoxy-butanoate is likely to be favorable in polar environments, particularly in higher temperature conditions, but it is advisable to consider specific experimental conditions when determining solubility in practice.

Interesting facts

Interesting Facts about 5,6,7,8-Tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-isopropyl-3-methoxy-butanoate

This complex organic compound is an intriguing example of the diverse world of nitrogen-containing heterocycles. Here are some interesting aspects of this compound:

  • Structural Uniqueness: The presence of the pyrrolidine ring in its structure contributes to its distinctive properties and reactivity patterns.
  • Biological Significance: Compounds with similar structures have been studied for their potential pharmaceutical applications, showcasing the relationship between structure and biological activity.
  • Combining Functional Groups: The compound contains multiple functional groups including hydroxyl and methoxy groups, which may enhance solubility and influence interactions with biological systems.
  • Synthetic Interest: The synthesis of this compound poses both challenges and opportunities for chemists. It can serve as a synthetic intermediate in the preparation of more complex molecules.

As a student of chemistry, exploring compounds like this can illustrate the intricacies of molecular design and its implications in medicinal chemistry. The study of such compounds fosters a deeper appreciation for the art of synthesis and the science behind drug development.

Moreover, in the words of renowned chemist Linus Pauling, “The best way to understand a chemical substance is to study its structure.” This compound is a perfect testament to that philosophy, illuminating how its unique molecular architecture can influence its behavior and interactions in chemical and biological settings.

Synonyms
(2R)-2-Hydroxy-2-[(R)-1-methoxyethyl]-3-methylbutanoic acid [(7aS)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl]methyl ester
5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate
DTXSID40964117
AKOS040734856
(2,3,5,7a-Tetrahydro-1H-pyrrolizin-7-yl)methyl 2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate