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Tacrine

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Identification
Molecular formula
C13H14N2
CAS number
321-64-2
IUPAC name
5,6,7,8-tetrahydroacridin-4-amine
State
State

At room temperature, tacrine is in a solid state, typically as a crystalline powder.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
458.90
Boiling point (Kelvin)
732.05
General information
Molecular weight
198.27g/mol
Molar mass
198.2740g/mol
Density
1.1813g/cm3
Appearence

Tacrine is a pale yellow to beige crystalline powder. It is often observed in its pure crystalline form and may appear slightly oily or shiny due to its solid state.

Comment on solubility

Solubility of 5,6,7,8-tetrahydroacridin-4-amine

5,6,7,8-tetrahydroacridin-4-amine is a fascinating compound with interesting solubility characteristics. Understanding its solubility can provide valuable insights into its chemical behavior and potential applications.

Key Points on Solubility:

  • Solvent Dependency: The solubility of 5,6,7,8-tetrahydroacridin-4-amine is highly dependent on the choice of solvent. Common polar solvents, such as water and alcohols, tend to enhance solubility due to their ability to interact with the amine functional group.
  • Hydrogen Bonding: The presence of the amino group can form hydrogen bonds with solvent molecules, which often increases solubility in polar solvents.
  • Saturation Points: Care should be taken to determine the saturation point of this compound in various solvents, as excessive concentrations may lead to precipitation.
  • Temperature Influence: The solubility may increase with temperature, typically observed in crystalline solids where higher temperatures provide energy to overcome lattice forces.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution, as protonation states of amines shift under different pH levels, thus altering their solubility characteristics.

It is crucial to consider these factors in practical applications, such as pharmacology and materials science, where solubility plays a pivotal role in efficacy and performance. As with many compounds, experimentation and empirical data are key to fully understanding the solubility behavior of 5,6,7,8-tetrahydroacridin-4-amine.

Interesting facts

Interesting Facts about 5,6,7,8-Tetrahydroacridin-4-amine

5,6,7,8-Tetrahydroacridin-4-amine is a fascinating compound with a rich background in both research and application. As a member of the acridine family, this compound showcases several intriguing characteristics:

  • Pharmacological Potential: Research indicates that compounds structurally similar to tetrahydroacridines have been investigated for various biological activities, including their potential use in treating neurodegenerative diseases like Alzheimer's. Their ability to interact with key neurotransmitter systems may provide new avenues for therapeutic intervention.
  • Structural Versatility: The unique tetrahydroacridine skeleton allows for various substitutions, which can lead to different pharmacological profiles. This structural adaptability makes it an interesting subject for synthetic chemists who aim to design novel compounds with specific properties.
  • Implications in Organic Synthesis: 5,6,7,8-Tetrahydroacridin-4-amine is often utilized in organic synthesis as a building block. This compound can serve as a precursor to more complex molecules, making it a valuable tool in the chemist's arsenal.
  • Research Opportunities: With ongoing studies into its properties, there are many unexplored pathways for research. This compound serves as a reminder of the vast potential that lies within organic compounds, just waiting to be uncovered.

In summary, 5,6,7,8-tetrahydroacridin-4-amine stands out due to its potential in medicinal chemistry, its versatile structure, and its significance in the field of organic synthesis. As advancements in science and technology continue, we can look forward to learning more about this intriguing compound!

Synonyms
1,2,3,4-Tetrahydro-5-aminoacridine
3198-41-2
CCRIS 2857
5-Amino-1,2,3,4-tetrahydroacridine
ACRIDINE, 1,2,3,4-TETRAHYDRO-5-AMINO-
4-Amino-2,3-tetramethylenequinoline
DTXSID30185814
DTXCID70108305
27L329C2QC
11-DEHYDROTETRAHYDROCORTICOSTERONE
UNII-27L329C2QC
SCHEMBL3792562
5,6,7,8-Tetrahydro-4-acridinamine
4-Acridinamine, 5,6,7,8-tetrahydro-