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(R)-N-Methylnipecotamide

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Identification
Molecular formula
C10H14N2O
CAS number
70037-25-3
IUPAC name
(5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one
State
State

At room temperature, (R)-N-Methylnipecotamide is typically found as a solid that may have an oily or liquid-like appearance if warmed slightly due to its melting point being close to room temperature.

Melting point (Celsius)
38.00
Melting point (Kelvin)
311.15
Boiling point (Celsius)
288.00
Boiling point (Kelvin)
561.15
General information
Molecular weight
178.24g/mol
Molar mass
178.2370g/mol
Density
1.1405g/cm3
Appearence

(R)-N-Methylnipecotamide is a colorless to pale yellow liquid. It can also appear as a crystalline solid depending on the conditions. In pure form, it lacks color and is often described as having an oily or slightly viscous quality.

Comment on solubility

Solubility of (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one

The solubility of (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one can be influenced by various factors including temperature, pH, and the presence of solvents. This compound, characterized by its unique molecular structure, demonstrates specific solubility properties that can be categorized as follows:

  • Polar solvents: The compound tends to be more soluble in polar solvents such as water and alcohols due to its pyridine ring and amide functional group.
  • Non-polar solvents: Conversely, it may show decreased solubility in non-polar solvents, reflecting the general trend seen with polar compounds.
  • Temperature influence: Increasing the temperature often enhances solubility, allowing for greater interaction between the solvent and solute molecules.
  • pH considerations: For some compounds, pH adjustments can significantly alter solubility; however, specific data on how pH affects this compound would require careful experimental analysis.

In summary, the solubility of (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one is predominantly influenced by its structure and environmental conditions. Understanding these solubility characteristics is essential for applications in synthesis and formulation.

Interesting facts

Interesting Facts About (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one

(5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one is a fascinating compound that falls under the category of pyrrolidine derivatives. Here are some intriguing aspects of this compound:

  • Structural Characteristics: The presence of a pyridine ring along with the pyrrolidine structure contributes to its unique chemical properties. Pyridine is known for its aromatic characteristics, which can influence the reactivity and stability of the entire molecule.
  • Biological Significance: Compounds like this one can play significant roles in pharmacology and are often studied for their potential biological activities. They may exhibit a range of effects including, but not limited to, neuroactive properties.
  • Sterochemistry: The designation of (5R) indicates a specific three-dimensional arrangement of atoms in the molecule. This stereochemistry is crucial, as even slight changes in the configuration can lead to profound differences in behavior and reactivity.
  • Applications: Compounds structurally similar to (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one have been investigated for applications in drug development, particularly in the fields of neuroscience and medicinal chemistry. They can be pivotal in designing new therapies for various diseases.
  • Research Potential: The ongoing research on derivatives of this compound may uncover additional properties and applications, particularly in targeting specific biological pathways or mechanisms, leading to the development of new therapeutic agents.

To sum it up, (5R)-1-methyl-5-(3-pyridyl)pyrrolidin-2-one is not just another chemical entity; it is a source of potential breakthroughs in medicinal chemistry and pharmacology. As researchers continue to explore its properties and derivatives, we may find it playing vital roles in the future of drug development.

Synonyms
R-(+)-Cotinine
32162-64-4
(5R)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
(R)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one
CAS-486-56-6
Lopac-C-5923
(5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
(5R)-(+)-1-Methyl-5-(3-pyridiyl)-2-pyrrolidinone
CHEMBL365343
SCHEMBL10899074
HY-B1178A
DTXSID401336690
TNP00100
EX-A11936
PDSP1_000114
PDSP2_000114
AKOS006277829
NCGC00015249-01
NCGC00016466-01
NCGC00016466-02
DA-57320
CS-0255536