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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(5S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

Solid: Corticosterone is a solid at room temperature and is typically available as a crystalline powder.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.00
Boiling point (Celsius)
443.90
Boiling point (Kelvin)
717.05
General information
Molecular weight
346.46g/mol
Molar mass
346.4610g/mol
Density
1.2000g/cm3
Appearence

Corticosterone is a white crystalline powder that can appear in various forms, including amorphous powder or crystalline solid, depending on its method of purification. It is generally odorless.

Comment on solubility

Solubility of (5S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of (5S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one can be analyzed through various factors influencing its dissolution in different solvents:

  • Polarity: This compound has a significant amount of non-polar hydrocarbons in its structure, indicating that it may be more soluble in non-polar solvents like hexane or toluene.
  • Hydrogen Bonding: The presence of the hydroxyl (-OH) group suggests some degree of solubility in polar solvents such as alcohols or water, though possibly limited due to the bulky hydrocarbon framework.
  • Temperature Dependency: Like many organic compounds, solubility is likely to increase with temperature, making higher temperatures favorable for its dissolution in both polar and non-polar solvents.

In conclusion, while the compound exhibits some solubility characteristics primarily due to its hydroxyl group, the extensive non-polar structure may limit its overall solubility in polar solvents. It is generally advisable to test solubility in a range of solvents to fully determine its dissolution properties.

Interesting facts

Interesting Facts about (5S)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

This compound is a fascinating molecule belonging to the class of steroids, and its structural complexity contributes to a wide variety of properties and biological functions. Here are some key points to appreciate about this compound:

  • Steroidal Framework: The structure consists of multiple interconnected carbon rings, which is characteristic of steroids. This framework plays a pivotal role in its biological activity.
  • Natural Occurrence: Compounds similar to it are often found in nature, particularly in plants and animal hormones, thus linking it to essential biochemical processes.
  • Functional Groups: The presence of hydroxy groups and several methyl groups introduces variability in its reactivity and interactions with biological systems.
  • Potential Applications: Researchers are interested in such compounds for their potential use in pharmaceuticals, particularly in therapies targeting hormonal or metabolic disorders.
  • Chirality Matter: The specific stereo configuration indicated by "(5S)" is crucial as it can greatly influence the biological activity of the compound, often determining the difference between therapeutic benefits and adverse effects.

The study of this compound emphasizes the importance of both its structural properties and biological relevance. The intricate balance between structure and function is a hallmark of many compounds in medicinal chemistry, making them both challenging and rewarding to explore.

In the words of some chemists, “Understanding the nuances of molecular structure is the key to unlocking nature’s secrets.” This compound serves as a prime example of how complex molecular arrangements can lead to significant biological outcomes.

Synonyms
SCHEMBL1650440
AKOS015901953