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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, corticosterone is in a solid state. It is commonly used in a crystalline powder form for scientific research.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.00
Boiling point (Celsius)
516.40
Boiling point (Kelvin)
789.60
General information
Molecular weight
346.47g/mol
Molar mass
346.4660g/mol
Density
1.2000g/cm3
Appearence

Corticosterone typically appears as a white or off-white crystalline powder. Its crystalline structure is characteristic of many steroid compounds.

Comment on solubility

Solubility of (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

The solubility of this complex compound can be influenced by various factors, given its intricate structure. Understanding its solubility properties is crucial for applications in pharmaceuticals and biochemical studies. Below are some key points regarding its solubility:

  • Solvent Dependence: The solubility of this compound may vary significantly in different solvents. Generally, it is expected to be more soluble in non-polar organic solvents due to its hydrophobic character.
  • Temperature Effects: As with many organic compounds, higher temperatures can enhance solubility. Care should be taken when conducting solubility tests at elevated temperatures to avoid degradation.
  • Potential Formulations: This compound could potentially be formulated in lipid-based systems to improve its solubility for therapeutic applications.
  • Comparative Solubility: The solubility can be compared against known benchmarks in the same class of compounds to gauge its effectiveness and usability.

In conclusion, while the specifics of the solubility of this compound may be limited, its solubility profile reflects a complex interaction of various physicochemical properties. Evaluating these characteristics is essential for optimizing its use in any applicable scientific or industrial fields.

Interesting facts

Interesting Facts about (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

This compound is a fascinating member of the steroid family, exhibiting a complex structure that is characteristic of many biologically active molecules. Its intricate arrangement of carbon atoms and functional groups plays a pivotal role in its reactivity and biological function.

Key Highlights:

  • Steroidal Framework: The compound is built upon a core steroid structure, which is crucial for many biological activities.
  • Hydroxyl Group Presence: The presence of a hydroxyl (-OH) group significantly impacts the compound’s solubility and interactions within biological systems.
  • Chirality: With multiple stereocenters, this compound showcases interesting chirality, meaning it has non-superimposable mirror images, affecting its pharmacological properties.
  • Biosynthesis: Like many sterols, this compound can be synthesized naturally in the body, showcasing the intricate biochemistry of steroid synthesis.
  • Pharmacological Importance: Investigating such compounds can lead to discoveries related to hormones, such as steroid hormones that regulate various physiological processes.

In the realm of chemistry research, studies surrounding this compound might reveal groundbreaking findings, particularly in the fields of endocrinology and pharmacology. As noted by a prominent chemist, “The complexity of steroid compounds holds the key to understanding vital biological mechanisms.” This emphasizes the importance of such compounds as not just chemical entities, but as vital tools in medical and biological research.

Understanding compounds like this one strengthens our grasp on the molecular basis of life and can lead to novel therapeutic strategies for a myriad of health conditions.

Synonyms
STANOLONE
Androstanolone
dihydrotestosterone
521-18-6
Andractim
Anabolex
Androlone
Neodrol
4-Dihydrotestosterone
5alpha-Dihydrotestosterone
Anaboleen
Stanaprol
Proteina
Protona
Cristerona MB
17beta-Hydroxy-5alpha-androstan-3-one
Androstanolona
Androstanolonum
5alpha-Androstan-17beta-ol-3-one
Testosterone, dihydro-
4,5alpha-Dihydrotestosterone
Stanolon
Stanorone
5alpha-DHT
17beta-Hydroxy-3-androstanone
dihydrotestosterone (dht)
5alpha-Dihydroxytestosterone
Androstan-17beta-ol-3-one
Androstanolonum [INN-Latin]
Androstanolona [INN-Spanish]
Androstanolone [INN]
4,5-alpha-Dihydrotestosterone
NSC 10972
5alpha,17beta-Hydroxyandrostan-3-one
CHEBI:16330
5alpha dihydrotestosterone
EINECS 208-307-3
Andractim (TN)
5.alpha.-Dihydrotestosterone
5alpha,17eta-Hydroxyandrostan-3-one
NSC-10972
5-a-Androstanolone
5-alpha-Androstan-17-beta-ol-3-one
5a-Dihydrotestosterone
Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-
Androstanolone (INN)
DTXSID9022364
5alpha-Androstan-3-one, 17beta-hydroxy-
5-alpha-Androstanolone
08J2K08A3Y
5-alpha-Androstan-3-one, 17-beta-hydroxy-
STANOLONE [MI]
4,5a-Dihydrotestosterone
(5-alpha,17-beta)-17-Hydroxyandrostan-3-one
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
Androstan-17b-ol-3-one
17b-Hydroxy-3-androstanone
17beta-Hydroxy-5alpha-androstane-3-one
17-Hydroxy-androstan-3-one
5a-Androstan-17b-ol-3-one
5A-Androstan-3-on-17B-ol
5B-Androstan-3-on-17B-ol
ANDROSTANOLONE [MART.]
DTXCID202364
ANDROSTANOLONE [WHO-DD]
(5alpha,17beta)-17-hydroxyandrostan-3-one
EC 208-307-3
NSC10972
17beta-hydroxy-3-oxo-5alpha-androstanone
TESTOSTERONE IMPURITY F [EP IMPURITY]
Androstanolonum (INN-Latin)
Androstanolona (INN-Spanish)
17.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-3-ONE
17.BETA.-HYDROXY-5.ALPHA.-ANDROSTANE-3-ONE
ANDROSTANOLONE (MART.)
5 alpha DHT
5-alpha-DHT
TESTOSTERONE IMPURITY F (EP IMPURITY)
5 alpha Dihydrotestosterone
5 alpha-Dihydrotestosterone
5-alpha Dihydrotestosterone
Dihydrotestosterone, 5-alpha
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo(8.7.0.02,7.011,15)heptadecan-5-one
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-5-one
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta(a)phenanthren-3-one
17beta Hydroxy 5alpha Androstan 3 One
THERAPEUTIC ANDROSTANOLONE
A14AA01
G03BB02
LG152
(5a,17b)-17-Hydroxyandrostan-3-one
5alpha-Androstan-3-one, 17beta-hydroxy-(8CI)
Androstan-3-one, 17-hydroxy-, (5alpha,17beta)-(9CI)
208-307-3
DHT
5-alpha-Dihydrotestosterone
Dihydrotestosteron
17beta-Hydroxyandrostan-3-one
17-beta-Hydroxy-5-alpha-androstan-3-one
5alpha-dihydrotesosterone
CHEMBL27769
4,5.alpha.-Dihydrotestosterone
17beta-Hydroxy-androstan-3-one
521-18-6 (free)
17.beta.-Hydroxy-3-androstanone
5.alpha.-Androstan-17.beta.-ol-3-one
NCGC00091013-01
5.alpha.,17.beta.-Hydroxyandrostan-3-one
[3H]DHT
BDBM50366473
Androstanolone (1mg/ml in Acetonitrile)
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one
CAS-521-18-6
5-.alpha.-Androstanolone
Androstanolone (1.0 mg/mL in Acetonitrile)
5.alpha.-Androstan-3-one, 17.beta.-hydroxy-
[3H]dihydrotestosterone
[3H]-dihydrotestosterone
Androstan-17.beta.-ol-3-one
17-beta-hydroxyandrostan-3-one
Androstan-3-one, 17-hydroxy-, (5.alpha.,17.beta.)-
Andrin
UNII-08J2K08A3Y
(+)-Androstan-17.beta.-ol-3-one
1kdk
2ama
Androstan-3-one, 17-hydroxy-, (5a,17b)-
5alpha-Androstanolone
Androstanolone (DHT)
17-.beta.-Hydroxy-5-.alpha.-androstan-3-one
1d2s
1t5z
1t7r
(5.alpha.,17.beta.)-17-Hydroxy-androstan-3-one
Epitope ID:135868
17-Hydroxyandrostan-3-one, (5.alpha.,17.beta.)- #
BIDD:PXR0075
SCHEMBL15163
MLS001304063
BIDD:ER0136
5.alpha.-Dihydroxytestosterone
GTPL2856
GTPL3455
BDBM18161
1t63
(+)-Androstan-17beta-ol-3-one
HMS2272H05
HY-A0120
Tox21_111056
Tox21_200987
Tox21_303655
LMST02020042
MSK8502-100A
s4757
AKOS015894892
CCG-267385
CS-5096
DB02901
GS-6587
NCGC00091013-02
NCGC00091013-03
NCGC00257456-01
NCGC00258540-01
AC-16144
AC-33095
SMR000058342
NS00005234
5alpha-Androstan-17beta-ol-3-one, >=97.5%
C03917
D07456
5Alpha-Dihydrotestosterone, 1mg/ml in Acetonitrile
Q411054
Androstanolone (5alpha-Dihydrotestosterone, Stanolone)
BRD-K22525962-001-05-0
Dihydrotestosterone Solution in Acetonitrile, 100ug/mL
5alpha-Androstan-17beta-ol-3-one, purum, >=99.0% (TLC)
5alpha-Androstan-17beta-ol-3-one, VETRANAL(TM), analytical standard
Androstanolone (5alpha-Dihydrotestosterone, Stanolone) 1.0 mg/ml in Acetonitrile
(5S,8R,10S,13S,17S)-17-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one
17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,10,11,12,13,14,15,16, 17-hexadecahydrocyclopenta[a]phenanthren-3-one