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Aldosterone

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Identification
Molecular formula
C21H28O5
CAS number
52-39-1
IUPAC name
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2-carbaldehyde
State
State

At room temperature, Aldosterone is typically a solid and is often handled as a powdered substance for medical and chemical usage.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
311.00
Boiling point (Kelvin)
584.15
General information
Molecular weight
360.45g/mol
Molar mass
360.4440g/mol
Density
0.8700g/cm3
Appearence

Aldosterone is typically a white to off-white, odorless, crystalline powder. Its appearance can vary between different preparations, but usually solid in form for handling in laboratory or pharmaceutical environments.

Comment on solubility

Solubility of (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2-carbaldehyde

The solubility of (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2-carbaldehyde can be quite intricate due to its complex structure and the presence of functional groups. Understanding its solubility properties may involve the following considerations:

  • Polarity: Given that the compound includes hydroxyl (-OH) groups, it may exhibit some degree of polarity, which could enhance its solubility in polar solvents such as water and alcohols.
  • Hydrophobic Characteristics: The extensive hydrocarbon structure suggests that the compound also possesses hydrophobic characteristics, which could limit its solubility in polar solvents.
  • Solvent Compatibility: Overall solubility may vary depending on the choice of solvent. For example, it could be more soluble in organic solvents such as ethanol, acetone, or chloroform than in water.

In conclusion, the solubility of this complex compound can be summarized as likely limited in polar environments, with enhanced solubility in organic solvents. Therefore, the choice of solvent is crucial when attempting to dissolve this compound for practical applications.

Interesting facts

Interesting Facts about (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2-carbaldehyde

This fascinating compound, often referred to in shorthand for practicality, showcases unique structural features that foster intriguing biochemical applications. The specific configuration of its stereocenters gives it interesting properties that can lead to various practical uses in organic synthesis and medicinal chemistry.

  • Stereo-specificity: The compound contains multiple stereogenic centers, making it a chiral molecule. This characteristic is critical in the field of pharmaceuticals, where the specific orientation of atoms can significantly affect biological activity and drug efficacy.
  • Functional Group Diversity: With a hydroxyl group and an aldehyde (–CHO) functional group, this compound can partake in numerous chemical reactions, such as oxidation, reduction, and nucleophilic additions, lending itself to versatile synthetic applications.
  • Biological Significance: Compounds with similar structures are often studied for their potential as hormone analogs due to their steroid-like frameworks. This could pave the way for new research into hormone replacement therapies or other medical innovations.
  • Environmental Interaction: Understanding the behavior of such compounds can aid in assessing their environmental impact, particularly with respect to their persistence and bioaccumulation potential in ecological systems.

As chemists continue to explore the vast chemical landscape, compounds like this one not only challenge our synthetic capabilities but also broaden our understanding of molecular interactions in biological systems. Always remember the words of Nobel Laureate Linus Pauling: “The best way to have a good idea is to have lots of ideas.” The study of complex molecules certainly stimulates this creative process!


Synonyms
601-16-1
NSC65889
17beta-Hydroxy-5alpha-androst-2-ene-2-carboxaldehyde
NSC 65889
2-Formyl-5-alpha-androst-2-en-17-beta-ol
17-beta-Hydroxy-5-alpha-androst-2-ene-2-carboxaldehyde
5-alpha-ANDROST-2-ENE-2-CARBOXALDEHYDE, 17-beta-HYDROXY-
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2-carbaldehyde
CHEBI:79540
DTXSID301231067
NSC-65889
Q27148644
(5I+/-,17I(2))-17-Hydroxyandrost-2-ene-2-carboxaldehyde