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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State
At room temperature, corticosterone is a solid crystalline substance. It is typically handled as a powder.
Melting point (Celsius)
182.00
Melting point (Kelvin)
455.00
Boiling point (Celsius)
518.00
Boiling point (Kelvin)
791.00
General information
Molecular weight
346.47g/mol
Molar mass
346.4670g/mol
Density
1.1900g/cm3
Appearence

Corticosterone is a white to off-white crystalline powder in appearance. It is usually solid at room temperature and does not exhibit significant color.

Comment on solubility

Solubility of (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of this compound, a complex polycyclic structure, can be influenced by various factors. Understanding its solubility characteristics is crucial, especially in fields like pharmaceuticals and biochemistry. Here are some key points to consider:

  • Polar vs. Non-polar: Given the significant hydrocarbon backbone, the compound is expected to exhibit a degree of non-polarity.
  • Solvent Type: It is likely to be more soluble in organic solvents such as ethanol, chloroform, or dimethyl sulfoxide (DMSO), rather than in polar solvents like water.
  • Hydroxyl Groups: The presence of multiple hydroxyl (-OH) groups may enhance solubility in some cases, particularly in alcoholic solutions, due to hydrogen bonding.

To summarize, the solubility of this compound can be described as:

  1. More soluble in non-polar organic solvents.
  2. Moderately soluble in polar organic solvents due to the functional groups present.
  3. Generally insoluble in water, consistent with many complex organic compounds.

As with any compound, the specific solubility will depend on temperature, pressure, and the presence of other solutes in the solution. Testing under controlled conditions is essential for accurate determination.

Interesting facts

Interesting Facts about (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This fascinating compound belongs to a class of chemical substances known for their numerous applications in medicinal chemistry and biochemistry. Here are some engaging facts worth noting:

  • Biological Significance: This compound is structurally related to steroids, which play vital roles in biological systems. Its unique arrangement of functional groups contributes to potential therapeutic activities, particularly in hormone regulation.
  • Research Potential: The complexity of its structure makes it a target for research in fields like drug development and pharmacology. Researchers have been investigating compounds with similar structures for their ability to modulate biological pathways.
  • Synthetic Challenges: The synthesis of this compound typically requires advanced organic chemistry techniques due to its multiple stereocenters and functional groups. As a result, finding efficient synthetic routes is an exciting challenge for organic chemists.
  • Natural Sources: Compounds of this nature are often derived from natural sources, including various plants and fungi, suggesting potential avenues for bioactive compounds that could lead to new pharmaceuticals.
  • Historical Context: The exploration of steroids and similar compounds has a rich history in chemistry. Many early studies set the groundwork for understanding molecular interactions that are crucial in pharmacology today.

In summary, the multifaceted nature of (5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one exemplifies the intersection of chemistry, biology, and medicine. The pursuit of understanding and harnessing its properties continues to inspire scientists and students alike.

Synonyms
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
CPD000058877
PD002933
17ss-Hydroxy-2-hydroxymethylen-17a-methyl-5a-androstan-3-on
Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17methyl-, (5.alpha.,17.beta.)
(1S,3aS,3bR,5aS,9aS,9bS,11aS)-1,7-dihydroxy-1,9a,11a-trimethyl-2H,3H,3aH,3bH,4H,5H,5aH,6H,9H,9bH,10H,11H-cyclopenta[a]phenanthrene-8-carbaldehyde