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Rapamycin

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Identification
Molecular formula
C51H79NO13
CAS number
53123-88-9
IUPAC name
[6-[2-[3-(11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-2,4,6,14,16-pentaen-2-yl)-2-hydroxy-1-methyl-butyl]-2-hydroxy-5-methyl-6-prop-1-enyl-tetrahydropyran-4-yl]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] carbamate
State
State

At room temperature, Rapamycin is in a solid state. Given its crystalline form, it is usually stored and handled as a powdered solid.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
548.40
Boiling point (Kelvin)
821.60
General information
Molecular weight
914.17g/mol
Molar mass
914.1720g/mol
Density
1.2000g/cm3
Appearence

Rapamycin is a macrolide compound that typically appears as a white to off-white crystalline powder. It is sensitive to light and should be stored protected from light to prevent degradation. The powder form is typically stable under recommended storage conditions.

Comment on solubility

Solubility of 6-[2-[3-(11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-2,4,6,14,16-pentaen-2-yl)-2-hydroxy-1-methyl-butyl]-2-hydroxy-5-methyl-6-prop-1-enyl-tetrahydropyran-4-yl]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl carbamate (C51H79NO13)

The solubility of this complex compound can be understood through several key factors:

  • Molecular Structure: The presence of multiple hydroxyl (-OH) groups in the structure often contributes to enhanced solubility in polar solvents, such as water.
  • Hydrophobic Regions: Simultaneously, the sizable hydrophobic portions of the molecule, indicated by the long carbon chains and various hydrophobic functional groups, may hinder solubility in aqueous environments.
  • Interaction with Solvents: Depending on the solvent, this compound may exhibit varied solubility ranges. For instance:
    • In polar solvents, it may dissolve relatively well due to hydrogen bonding.
    • In non-polar solvents, solubility is likely to be poorer due to the balance of hydrophilic and hydrophobic characteristics.
  • Temperature Effects: As a general rule, increasing temperature tends to improve solubility for many organic compounds.
  • pH Influence: The solubility can also be affected by pH levels, especially given the existence of functional groups that can gain or lose protons.

In summary, the solubility of this carbamate compound is expected to be conditional, influenced by the type of solvent used, temperature, and pH. Understanding these factors is crucial for practical applications and further research.

Interesting facts

Interesting Facts about 6-[2-[3-(11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-2,4,6,14,16-pentaen-2-yl)-2-hydroxy-1-methyl-butyl]-2-hydroxy-5-methyl-6-prop-1-enyl-tetrahydropyran-4-yl]oxy-4-hydroxy-2-methyl-tetrahydropyran-3-yl] carbamate

This complex organic compound showcases an impressive molecular structure, indicative of its potential biological activity and chemical versatility. Here are some fascinating insights:

  • Unique Structure: The presence of a tetramethyl and multiple hydroxy groups suggests that it may interact with multiple biological pathways, making it an interesting candidate for further studies in biochemistry.
  • Derived Properties: The compound's multiple functional groups, including carbamate and tetrahydropyran, highlight its potential reactivity, yielding valuable insights into its application in medicinal chemistry.
  • Biological Relevance: Compounds with similar functional groups have been studied for their roles in medicinal properties and applications in pharmacology. The specific modifications in this particular compound could enhance its bioactivity.
  • Environmental Considerations: Understanding the synthesis and breakdown of this compound could provide important insights into its stability and ecological impact.

As you explore this compound, consider the myriad possibilities it offers in the field of organic synthesis and therapeutic applications. Its intricate design not only captures the complexity of chemical compounds but also reflects how chemistry continually evolves, unveiling new frontiers in science.