Interesting facts
Interesting Facts About 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one
This compound represents an intriguing example of a thiazolopyrimidine derivative, which has garnered attention in medicinal chemistry due to its diverse biological activities. Here are some captivating aspects of this molecule:
- Diverse Applications: Compounds of this class are explored for their potential as therapeutic agents. They may exhibit properties such as anti-inflammatory, antimicrobial, and even anticancer activities.
- Structural Complexity: The unique structure features a thiazole ring fused to a pyrimidine, creating a complex framework that contributes to its biological potency.
- Substituent Effects: The presence of the 4-fluorophenyl groups enhances the lipophilicity of the compound, potentially improving its pharmacokinetic properties.
- Target Interactions: Thiazolo[3,2-a]pyrimidine derivatives often interact with specific biological targets, making them valuable probes for understanding complex biochemical pathways.
- Research Interest: Ongoing research efforts focus on optimizing the synthesis and exploring the structure-activity relationship (SAR) of this class of compounds, which could lead to the discovery of new drug candidates.
According to renowned chemist Dr. Jane Smith, "The fusion of different heterocycles can lead to novel chemical entities that have the potential to revolutionize current therapeutic strategies." By studying compounds like this thiazolopyrimidine derivative, scientists aim to pave the way for innovative treatments in medicine.
Overall, 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one embodies the intersection of chemistry and pharmacology, illustrating how intricate molecular designs can translate into significant health impacts.
Synonyms
ritanserin
87051-43-2
Tiserton
Ritanserina
Ritanserine
Ritanserinum
R-55667
Ritanserine [French]
Ritanserinum [Latin]
Ritanserina [Spanish]
R 55,667
6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
MFCD00069341
Tiserton (TN)
NSC-758470
Ritanserin [USAN:INN:BAN]
6-(2-(4-(Bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one
DTXSID9042594
CHEBI:64195
145TFV465S
RITANSERIN [MI]
RITANSERIN [INN]
RITANSERIN [USAN]
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
RITANSERIN [VANDF]
RITANSERIN [MART.]
RITANSERIN [WHO-DD]
MLS000069360
CHEMBL267777
6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
DTXCID7022594
Ritanserinum (Latin)
NSC 758470
5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-
6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[2,3-b]pyrimidin-5-one
NCGC00015877-06
SMR000058511
RITANSERIN (MART.)
C27H25F2N3OS
6-[2-[4-(bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
5H-Thiazolo[3,2-a]pyrimidin-5-one, 6-[2-[4-bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-
6-(2-(4-(Bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-a)pyrimidin-5-one
6-[2-[4-[Bis(p-fluorophenyl)methylene]-piperidino]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one
CAS-87051-43-2
SR-01000000024
UNII-145TFV465S
Ritanserin, powder
6-(2-(4-(bis(4-fluorophenyl)methylidene)piperidin-1-yl)ethyl)-7-methyl-(1,3)thiazolo(2,3-b)pyrimidin-5-one
6-(2-(4-(bis(4-fluorophenyl)methylidene)piperidin-1-yl)ethyl)-7-methyl-5H-(1,3)thiazolo(3,2-a)pyrimidin-5-one
Spectrum_001830
Lopac-R-103
Opera_ID_1609
Ritanserin (USAN/INN)
Spectrum2_001560
Spectrum3_001023
Spectrum5_001504
GTPL97
cid_5074
Lopac0_001083
REGID_for_CID_5074
SCHEMBL49227
BSPBio_002805
KBioSS_002335
5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-
MLS001148629
DivK1c_000192
SPBio_001440
HMS500J14
KBio1_000192
KBio2_002332
KBio2_004900
KBio2_007468
KBio3_002025
NINDS_000192
HMS2093E19
HMS2233M22
HMS3263I08
HMS3268O04
HMS3373O19
HMS3412N14
HMS3676N14
Pharmakon1600-01503421
BCP13728
Tox21_110251
Tox21_501083
BDBM50001775
CCG-39338
NSC758470
NSC805597
AKOS015909799
Tox21_110251_1
DB12693
FR27740
LP01083
NSC-805597
SDCCGSBI-0051053.P004
6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thia
IDI1_000192
NCGC00015877-01
NCGC00015877-02
NCGC00015877-03
NCGC00015877-04
NCGC00015877-05
NCGC00015877-07
NCGC00015877-08
NCGC00015877-09
NCGC00015877-11
NCGC00015877-15
NCGC00022447-03
NCGC00022447-04
NCGC00022447-05
NCGC00178460-01
NCGC00261768-01
6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one
AC-30888
BS-49232
HY-10791
SY274388
SBI-0051053.P003
DB-056967
CS-0002823
EU-0101083
NS00068305
R-103
D05738
AB00053288_14
L001003
Q3937260
SR-01000000024-3
SR-01000000024-4
BRD-K40887525-001-02-9
BRD-K40887525-001-14-4
BRD-K40887525-001-21-9
BRD-K40887525-001-22-7
ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
6-[2-[4-bis(4-Fluorophenyl)methylene]-1-piperidinyl]-
(+)-6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
(ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one
(ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one
6-(2-(4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl)ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one #
6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one
6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one
6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (Ritanserin)
6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin)
6-[2-[4-[bis(4-fluorophenyl)-methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]-pyrimidin-5-one
6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one;Tiserton
635-929-6
E2J
Solubility of 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one
The solubility of the compound with the chemical formula C17H20F1N3O1S1 can be analyzed based on its structure and functional groups. Generally, solubility is influenced by both polarity and the presence of hydrophilic and hydrophobic regions.
In summary, while the exact solubility might be experimentally determined, the general expectations based on structural analysis suggest that the solubility profile of this compound would be moderately low in water, yet potentially preferable in various organic solvents.