Skip to main content

Ceftriaxone

ADVERTISEMENT
Identification
Molecular formula
C18H18N8O7S3
CAS number
73384-59-5
IUPAC name
6-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
State
State

At room temperature, Ceftriaxone is typically in a solid state. It is available in powder form, which should be reconstituted for injection as a solution.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
341.40
Boiling point (Kelvin)
614.55
General information
Molecular weight
554.58g/mol
Molar mass
554.5770g/mol
Density
1.7003g/cm3
Appearence

Color and Form: Ceftriaxone is usually available as a white to slightly yellow crystalline powder.

Solubility: It is freely soluble in water, sparingly soluble in methanol, and very slightly soluble in ethanol.

Comment on solubility

Solubility of 6-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

The solubility of the compound C18H18N8O7S3 can be described as follows:

  • Polarity: The presence of multiple functional groups such as amides and carboxylates suggests that the compound is likely to exhibit polar characteristics, which can enhance solubility in polar solvents like water.
  • Hydrogen Bonding: The amine and carbonyl groups contribute to potential hydrogen bonding, which is beneficial for solubility in aqueous solutions.
  • Stability: The presence of sulfur atoms in the structure may affect stability and solubility; thiol or thioether groups can influence interactions with solvents.
  • Solvent Dependency: Solubility may vary considerably between different solvents. Polar solvents are expected to provide better solubility compared to non-polar solvents.
  • Temperature Effect: Generally, increasing the temperature tends to improve solubility for many compounds, potentially facilitating its dissolution in various solvents.

Overall, while the exact solubility profile may require specific experimental determination, the characteristics outlined represent a good starting point for understanding how this complex molecule interacts with solvents.

Interesting facts

Interesting Facts about 6-[[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

This compound is a member of the class of chemical compounds known as thiazolidinediones, which have garnered significant interest in medicinal chemistry, particularly for their potential therapeutic applications. Here are some fascinating aspects of this compound:

  • Structural Complexity: The intricate bicyclic structure of this compound, particularly the thia and azabicyclo rings, showcases the versatility of organic chemistry in synthesizing complex molecules with potential bioactivity.
  • Functional Groups: This compound features an array of functional groups, including amides and carboxylates, which often play critical roles in pharmacological effectiveness. These groups can facilitate interactions with biological targets.
  • Potential Biological Activity: With its unique combination of features, this compound could exhibit significant biological activity. Compounds with similar structures have been studied for their potential to inhibit certain enzymes linked to various diseases.
  • Synthetic Pathways: The synthesis of this compound is likely to involve multiple steps, including protection-deprotection strategies and coupling reactions, emphasizing the need for advanced skills in synthetic organic chemistry.

As the field of medicinal chemistry continues to evolve, compounds like this one provide a rich avenue for research and discovery. The ongoing study of their mechanisms and potential applications is crucial in the search for novel therapeutic agents. In the words of a famous chemist, "The perfect structure can lead to the perfect function." Thus, understanding these complex structures can open doors to groundbreaking medical advancements.

Synonyms
6-{[{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
STK249732
AKOS000715107
AKOS022066806