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Penicillin G

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Identification
Molecular formula
C16H18N2O4S
CAS number
61-33-6
IUPAC name
6-[(2-allylsulfanylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;2-(diethylamino)ethyl 4-amino-2-chloro-benzoate
State
State

At room temperature, Penicillin G is typically found in a solid state as a powder. It is commonly used in this form for preparation into various pharmaceutical dosage forms.

Melting point (Celsius)
103.00
Melting point (Kelvin)
376.15
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
334.39g/mol
Molar mass
334.3890g/mol
Density
1.3200g/cm3
Appearence

Penicillin G is typically a white to off-white crystalline powder. It is odorless and can be found in both powder and solution forms for various pharmaceutical applications.

Comment on solubility

Solubility Characteristics

The compound 6-[(2-allylsulfanylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;2-(diethylamino)ethyl 4-amino-2-chloro-benzoate exhibits notable solubility properties influenced by its complex structure. Understanding the solubility of such compounds is crucial for their practical applications, especially in pharmaceutical and chemical industries.

Solubility Insights:

  • Polarity Consideration: The presence of multiple functional groups, including amino (-NH2), carboxylic acid (-COOH), and diethylamino groups, suggests varied polarity that can affect solubility in different solvents.
  • Water Solubility: Compounds with carboxylic acid groups often have increased water solubility due to hydrogen bonding. Thus, one might expect that part of this compound could dissolve well in water.
  • Organic Solvents: The diethylamino component may enhance solubility in organic solvents, potentially making the compound soluble in substances like ethanol or acetone.
  • pH Dependent: The solubility might also be pH-dependent—at lower pH values, the carboxylic acid could be protonated, affecting solubility profiles in aqueous environments.

In conclusion, the solubility of this compound is likely to be a complex interplay of its structural attributes and environmental conditions. As with many multicomponent structures, evaluating solubility is essential for manipulating the compound in practical scenarios.

Interesting facts

Interesting Facts about 6-[(2-allylsulfanylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 2-(diethylamino)ethyl 4-amino-2-chloro-benzoate

This compound is a fascinating example of the intersection between medicinal chemistry and organic synthesis. Here are some interesting insights:

  • Dual Functionality: This compound comprises two distinct functional groups that may provide unique properties and functionalities in therapeutic settings. The bicyclic structure is known for its stability and versatility in drug design.
  • Potential Pharmacological Properties: Compounds that contain bicyclic thioether frameworks are often investigated for their antimicrobial, anti-inflammatory, or even anticancer activities. The incorporation of the diethylamino moiety suggests suitability for designing selective receptor antagonists.
  • Synthetic Routes: The complexity of this compound's structure represents a challenge for chemists. The synthesis may involve various reactions such as acylation, coupling, and formation of heterocycles, making it a great case study in organic reaction mechanisms.
  • Structure-Activity Relationship (SAR): Analyzing the changes in biological activity when substituents on this compound are altered is essential in drug development. Modifying the 2-allylsulfanyl or the 2-(diethylamino)ethyl groups could offer insights into enhancing efficacy and reducing side effects.
  • Interdisciplinary Research: This compound's potential applications could transcend mere pharmacology, inviting research from fields like materials science, where derivatives could serve as precursors in creating advanced materials.

As highlights from ongoing research illuminate the importance of structural complexity and functional groups, this compound stands as a testament to the innovation chemical scientists pursue in developing novel therapeutic agents. The interplay between its unique structural elements makes it a compelling subject for further exploration in both academic and pharmaceutical realms.

Synonyms
575-52-0
C26-H37-Cl-N4-O6-S2
DTXSID70973035
6-({1-Hydroxy-2-[(prop-2-en-1-yl)sulfanyl]ethylidene}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid--2-(diethylamino)ethyl 4-amino-2-chlorobenzoate (1/1)