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Lamotrigine

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Identification
Molecular formula
C9H7Cl2N5
CAS number
84057-84-1
IUPAC name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
State
State

Lamotrigine is generally encountered as a solid at room temperature.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
256.09g/mol
Molar mass
256.0920g/mol
Density
1.3000g/cm3
Appearence

Lamotrigine is a white to pale cream-colored crystalline powder.

Comment on solubility

Solubility of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

The solubility of the compound 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (C9H7Cl2N5) can be influenced by several factors. Understanding the solubility behavior of this chemical is crucial for its application in various fields. Here are some key points regarding its solubility:

  • Polarity: The presence of chlorine atoms in the compound often increases its polarity, which can affect its solubility in polar solvents.
  • Solvent Interaction: This compound may exhibit good solubility in organic solvents such as dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), but may show limited solubility in water due to its hydrophobic characteristics.
  • Temperature Effects: Like many chemical compounds, its solubility can vary with temperature. Typically, increased temperature can enhance solubility.
  • pH Influence: The ionization state of the amino groups may affect solubility, potentially increasing in basic conditions.

Thus, when considering the solubility of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, it is important to evaluate the solvent used, temperature, and pH level, as these factors collectively contribute to its overall solubility profile. As always, conducting empirical tests under varying conditions helps in establishing accurate solubility data for practical applications.

Interesting facts

Interesting Facts About 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

This fascinating compound belongs to the family of triazines, which are heterocyclic compounds known for their versatile chemical properties. With its unique structure, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine has garnered interest in various fields, particularly in medicinal chemistry and agricultural applications.

Key Features

  • Complex Structure: The presence of chlorine substituents on the phenyl ring enhances the compound's reactivity and can influence its biological activity.
  • Potential Pharmaceutical Applications: Compounds like this triazine derivative often serve as building blocks for the synthesis of novel medicinal agents, showcasing promising activity against certain diseases.
  • Agricultural Relevance: Triazine compounds are widely studied for their herbicidal properties, making them significant in crop protection and management strategies.
  • Research on Mechanism: Studies often focus on the mechanisms of action of triazine derivatives in biological systems, exploring how they interact with specific receptors or enzymes.

“Understanding the chemistry behind triazines opens doors to new discoveries in pharmaceuticals and agrochemicals.”

As research progresses, the implications of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine could lead to innovative solutions in health and agriculture. Its diverse applications hinge on a deep understanding of its chemical properties and biological interactions, making it a compound of significant interest among chemists today.

Synonyms
lamotrigine
84057-84-1
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Lamictal
Lamictal Cd
Lamotrigina
Lamictal XR
Lamotriginum
Lamitor
BW 430C
Lamotriginum [Latin]
Lamictal ODT
Lamotrigina [Spanish]
BW-430C
Labileno
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
C9H7Cl2N5
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
MFCD00865333
EINECS 281-901-8
LTG;BW430C
NSC-759171
UNII-U3H27498KS
CHEBI:6367
DTXSID2023195
HSDB 7526
U3H27498KS
CHEMBL741
MLS000069685
DTXCID203195
Lamotrigine [USAN:USP:INN:BAN]
Lamotriginum (Latin)
NSC 746307
NSC 759171
NCGC00015605-06
SMR000058464
LAMOTRIGINE (MART.)
LAMOTRIGINE [MART.]
LAMOTRIGINE (USP-RS)
LAMOTRIGINE [USP-RS]
LAMOTRIGINE (EP IMPURITY)
LAMOTRIGINE [EP IMPURITY]
(6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
LAMOTRIGINE (EP MONOGRAPH)
LAMOTRIGINE (USP IMPURITY)
LAMOTRIGINE [EP MONOGRAPH]
LAMOTRIGINE [USP IMPURITY]
LAMOTRIGINE (USP MONOGRAPH)
LAMOTRIGINE [USP MONOGRAPH]
1,2,4-TRIAZINE-3,5-DIAMINE, 6-(2,3-DICHLOROPHENYL)
Lamotrigine (USAN:USP:INN:BAN)
Lamictal (TN)
CAS-84057-84-1
BW430C
SR-01000000187
Lamotirigine
Epilepax
Lamotrigine ER
EUR-1048
IYJ
LAMOTRIGINEKit
zine-3,5-diamine
LAMICTALODT
LAMICTALXR
SUBVENITE
GI 267119X
Opera_ID_12
Lamotrigine (Standard)
Tocris-1611
LAMOTRIGINE [MI]
LAMOTRIGINE [INN]
LAMOTRIGINE [JAN]
Lopac-L-3791
LAMOTRIGINE [HSDB]
LAMOTRIGINE [USAN]
L 3791
lamotrigine extended-release
Lamotrigine Extended Release
Lopac0_000688
SCHEMBL35439
LAMOTRIGINE [WHO-DD]
MLS000759486
MLS001077325
MLS001423991
BIDD:GT0794
Lamotrigine (JAN/USP/INN)
lamotrigine chewable dispersible
Lamotrigine, >=98%, powder
GTPL2622
Lamotrigine, 1mg/ml in Ethanol
Lamotrigine - Bio-X trade mark
HY-B0495R
LAMOTRIGINE [ORANGE BOOK]
N03AX09
HMS2051C10
HMS2089M08
HMS2093P21
HMS2230L04
HMS3262I17
HMS3268G17
HMS3371O16
HMS3393C10
HMS3657A17
HMS3715H21
HMS3885M03
Pharmakon1600-01505610
BCP12156
HY-B0495
Lamotrigine 1.0 mg/ml in Methanol
Tox21_110179
Tox21_500688
BDBM50031299
HB0368
NSC746307
NSC759171
s3024
STK628377
AKOS005561147
Tox21_110179_1
6-(2,2,4-triazine-3,5-diyldiamine
CCG-100856
DB00555
ID58057
KS-1074
LP00688
NC00106
NSC-746307
SDCCGSBI-0050666.P003
SMP2_000303
NCGC00015605-01
NCGC00015605-02
NCGC00015605-03
NCGC00015605-04
NCGC00015605-05
NCGC00015605-07
NCGC00015605-08
NCGC00015605-09
NCGC00015605-10
NCGC00015605-23
NCGC00015605-24
NCGC00022936-02
NCGC00022936-04
NCGC00022936-05
NCGC00261373-01
AC-10298
AC-32483
BL166799
Lamotrigine 100 microg/mL in Acetonitrile
SBI-0050666.P002
6-(2,3-Dichloro-phenyl)-[1,2,4]tria
DB-014839
EU-0100688
L0241
NS00000354
SW197486-3
D00354
EN300-120680
W13018
AB00384359-16
AB00384359_17
AB00384359_18
Q410346
3,5-diamino-(2,3-dichlorophenyl)-1,2,4-triazine
SR-01000000187-2
SR-01000000187-4
SR-01000000187-7
BRD-K93460210-001-22-9
BRD-K93460210-001-23-7
BRD-K93460210-071-01-6
SR-01000000187-10
3,5-diamino-6-(2,3,-dichlorophenyl)-1,2,4-triazine
F2173-0540
Z1532338577
6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamine
Lamotrigine, British Pharmacopoeia (BP) Reference Standard
Lamotrigine, European Pharmacopoeia (EP) Reference Standard
6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamine(lamotrigine)
GI 267119X; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Lamotrigine, United States Pharmacopeia (USP) Reference Standard
Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material
Lamotrigine for peak identification, European Pharmacopoeia (EP) Reference Standard
Lamotrigine for system suitability, European Pharmacopoeia (EP) Reference Standard
281-901-8
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine