Skip to main content

Cloxacillin

ADVERTISEMENT
Identification
Molecular formula
C19H17ClN3O5S
CAS number
61-72-3
IUPAC name
6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
State
State

At room temperature, cloxacillin is typically in solid form as a crystalline powder. This state is suitable for its storage and use in manufacturing, especially in the pharmaceutical industry.

Melting point (Celsius)
178.50
Melting point (Kelvin)
451.65
Boiling point (Celsius)
-221.15
Boiling point (Kelvin)
490.30
General information
Molecular weight
435.89g/mol
Molar mass
435.8880g/mol
Density
1.3184g/cm3
Appearence

Cloxacillin appears as a white or slightly yellow crystalline powder. It is typically supplied in the form of sodium cloxacillin, which is a salt, enhancing its solubility in water. This compound is odorless and is used in a broad spectrum of applications including pharmaceutical formulations.

Comment on solubility

Solubility Characteristics

The compound 6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, with the chemical formula C19H17ClN3O5S, presents a complex solubility profile influenced by its chemical structure.

Solubility Insights

Key points regarding the solubility of this compound include:

  • Polarity: This compound contains polar functional groups such as carboxylate and amine, which may enhance its solubility in polar solvents like water.
  • Chlorine Substitution: The presence of the chlorine atom in the phenyl ring can affect hydrophobic interactions, potentially decreasing solubility in aqueous environments.
  • Steric Factors: The complex bicyclic structure and bulky substituents may hinder the compound's ability to solvate, leading to a lower solubility overall.

Overall, the solubility of this compound may be categorized as moderate to low in water. As often observed in similar compounds, it may exhibit better solubility in organic solvents such as DMSO or acetone. Further experimental evaluations are essential to determine precise solubility parameters for practical applications.

Interesting facts

Interesting Facts about 6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

This compound is a fascinating example of a complex organic molecule, showcasing the intricate relationship between structure and function in medicinal chemistry. Here are some intriguing points regarding its characteristics and applications:

  • Biological Activity: Many compounds that contain isoxazole rings exhibit significant biological activities, often serving as lead compounds in drug discovery. The isoxazole functionality in this molecule suggests potential pharmacological relevance.
  • Antimicrobial Properties: Compounds related to azabicyclo structures have been researched for their potential antimicrobial properties. This may carry significance in developing new antibiotics or antimicrobial agents.
  • Medicinal Chemistry: The compound features a unique bicyclic framework which is often explored in developing novel therapeutic agents. The incorporation of sulfur and its related functionalities could open up avenues for various applications in pharmaceuticals.
  • Structure-Activity Relationship (SAR): Understanding how modifications to the molecular structure affect its activity could lead to valuable insights in designing more effective drugs based on this compound.
  • Environmental Impact: Given that some chlorinated compounds can raise environmental concerns, the synthesis and degradation pathways of this molecule could be of interest in the context of green chemistry and environmental sustainability.

This compound not only serves as a valuable piece of research in the laboratory but also illustrates the beauty of chemical diversity and the potential for creating innovative solutions in healthcare and beyond. As noted by chemist Marie Curie, "One never notices what has been done; one can only see what remains to be done." This sentiment resonates deeply in the pursuit of advancing chemical sciences.


Through ongoing research, the exploration of such compounds can yield new horizons in understanding and addressing various challenges in health and industry.

Synonyms
6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
STK177351
AKOS001700670
AKOS022008360
CCG-117428
6-[3-(2-CHLOROPHENYL)-5-METHYL-1,2-OXAZOLE-4-AMIDO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE