Skip to main content

Coenzyme Q10

ADVERTISEMENT
Identification
Molecular formula
C59H90O4
CAS number
303-98-0
IUPAC name
6-[[4-[2-[2-[3-acetamido-5-hydroxy-2-[hydroxy-[hydroxy(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl]oxy-phosphoryl]oxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-2-amino-7-[[2-(1-carboxyethylamino)-1-methyl-2-oxo-ethyl]amino]-7-oxo-heptanoic acid
State
State

At room temperature, Coenzyme Q10 is in a solid state, specifically a crystalline powder. Its distinct yellow-orange color is due to its long polyisoprenoid tail, which is common in compounds involved in cellular respiration.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.00
Boiling point (Celsius)
545.60
Boiling point (Kelvin)
818.80
General information
Molecular weight
863.37g/mol
Molar mass
863.3650g/mol
Density
1.5900g/cm3
Appearence

Coenzyme Q10 appears as a yellow to orange crystalline powder. It is insoluble in water but soluble in organic solvents like ethanol and oils, providing its characteristic color to these solutions.

Comment on solubility

Solubility of 6-[[4-[2-[2-[3-acetamido-5-hydroxy-2-[hydroxy-[hydroxy(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl]oxy-phosphoryl]oxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-2-amino-7-[[2-(1-carboxyethylamino)-1-methyl-2-oxo-ethyl]amino]-7-oxo-heptanoic acid (C59H90O4)

The solubility of a compound like 6-[[4-[2-[2-[3-acetamido-5-hydroxy-2-[hydroxy-[hydroxy(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl]oxy-phosphoryl]oxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-2-amino-7-[[2-(1-carboxyethylamino)-1-methyl-2-oxo-ethyl]amino]-7-oxo-heptanoic acid is complex due to its intricate structure and numerous functional groups. Here are some considerations regarding its solubility:

  • Hydrophilicity and Hydrophobicity: The presence of multiple hydroxyl (-OH) groups and phosphonate functionalities enhances the compound's affinity for water, suggesting potential hydrophilicity.
  • Chain Length: The extensive undecamethyltetratetraconta chain introduces hydrophobic characteristics that can impact overall solubility in aqueous solutions.
  • pH Dependency: The acid groups present (such as carboxylic acid) can influence solubility depending on the pH of the solution, potentially leading to increased solubility at physiological pH levels.
  • Structural Complexity: The intricate architecture of the molecule may further complicate solubility patterns, as steric hindrance from bulky groups can affect interaction with solvents.

In summary, while the numerous polar functional groups may suggest a tendency towards solubility in polar solvents, the hydrophobic parts of the molecule might counteract this effect. Testing the solubility in various solvent systems will provide a clearer picture of the solubility characteristics of this compound.

Interesting facts

Interesting Facts about 6-[[4-[2-[2-[3-acetamido-5-hydroxy-2-[hydroxy-[hydroxy(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl]oxy-phosphoryl]oxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-2-amino-7-[[2-(1-carboxyethylamino)-1-methyl-2-oxo-ethyl]amino]-7-oxo-heptanoic acid

This compound, often referred to as a complex bioconjugate, showcases an intricate arrangement of molecular functionalities that play vital roles in various biochemical processes. Here are some captivating insights about it:

  • Chemical Complexity: The structure contains multiple amino acid moieties, making it a potentially important molecule in peptide-based therapies.
  • Enzymatic Interactions: Due to its high number of hydroxyl groups and amide functionalities, this compound may interact favorably with enzymes, contributing to its possible applications in drug design.
  • Biocompatibility: Many of its components are derived from naturally occurring compounds, suggesting its potential for biocompatibility in pharmaceutical applications.
  • Applications in Drug Delivery: The phosphoryl groups might enhance the solubility and stability of the molecule, making it an excellent candidate for drug delivery systems.
  • Research Potential: Its complex structure provides a wide array of research avenues, including its use as a model compound for studying lipid-bilayer interaction and cellular uptake mechanisms.

As biochemistry continues to evolve, molecules like this one contribute valuable insights into the design of next-generation therapeutics. Understanding such compounds' intricate structures and functions will allow chemists and biologists alike to harness their full potential in medicine and biotechnology.