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Olanzapine

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Identification
Molecular formula
C17H20N4O2S
CAS number
132539-06-1
IUPAC name
6-(4-methylpiperazin-1-yl)-8-methylsulfonyl-benzo[b][1,4]benzoxazepine
State
State

Solid: At room temperature, olanzapine is in a solid state. It is known for its stability and can be handled safely under normal conditions.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
387.90
Boiling point (Kelvin)
661.05
General information
Molecular weight
312.44g/mol
Molar mass
312.4440g/mol
Density
1.1900g/cm3
Appearence

Olanzapine appears as a pale yellow crystalline solid. It is practically insoluble in water but soluble in some organic solvents.

Comment on solubility

Solubility of 6-(4-methylpiperazin-1-yl)-8-methylsulfonyl-benzo[b][1,4]benzoxazepine

When assessing the solubility of 6-(4-methylpiperazin-1-yl)-8-methylsulfonyl-benzo[b][1,4]benzoxazepine, several factors come into play:

  • Polarity: The presence of functional groups such as the -methylpiperazine and -methylsulfonyl can significantly influence its solubility in polar solvents.
  • Solvent Compatibility: This compound may exhibit varying solubility in different solvents; it’s likely to be soluble in polar aprotic solvents but may have limited solubility in non-polar solvents.
  • Temperature Dependence: Solubility is typically temperature-dependent, with increased temperatures often increasing solubility for solid compounds.
  • pH Sensitivity: If the compound contains acidic or basic groups, pH can affect its ionization state, thereby altering solubility in aqueous solutions.

In summary, while definitive solubility data for this specific compound might be limited, understanding its structural characteristics provides valuable insights into its potential solubility behavior. As with many chemical compounds, performing empirical tests in various solvents will yield the most accurate results. Always consider the thermodynamic and kinetic factors that might affect solubility in real-world applications.

Interesting facts

Interesting Facts about 6-(4-methylpiperazin-1-yl)-8-methylsulfonyl-benzo[b][1,4]benzoxazepine

6-(4-methylpiperazin-1-yl)-8-methylsulfonyl-benzo[b][1,4]benzoxazepine is a fascinating compound within the field of medicinal chemistry. Here are some noteworthy aspects to consider:

  • Structural Complexity: This compound features a unique structural framework known as the benzoxazepine core, which is characterized by a fused benzene and oxazepine ring. Such a configuration is often associated with significant biological activity.
  • Pharmacological Potential: Compounds incorporating a piperazine moiety have been linked to various pharmacological effects, including but not limited to antidepressant, anxiolytic, and antipsychotic activities. This compound's dual functionality may open up avenues for research into novel therapeutic agents.
  • Sulfonyl Group Activity: The presence of a methylsulfonyl group enhances the compound’s lipophilicity, potentially improving its bioavailability. Sulfonamide derivatives are known for their antibacterial properties, making this aspect particularly interesting.
  • Research Applications: Owing to its intricate structure and promising biological properties, this compound is often the subject of study in drug development programs aimed at treating various neurological disorders.

"Understanding complex compounds like this is key to unlocking new possibilities in therapeutic interventions."

As research continues to evolve in this area, it is exciting to contemplate the potential impact of such compounds on the future of pharmacology and medicinal chemistry!

Synonyms
DIBENZ(b,f)(1,4)OXAZEPINE, 11-(4-METHYL-1-PIPERAZINYL)-2-(METHYLSULFONYL)-
22000-66-4
11-(4-Methyl-1-piperazinyl)-2-(methylsulfonyl)dibenz(b,f)(1,4)oxazepine
BRN 0582437
11-(4-Methyl-1-piperazinyl)-2-(methylsulfonyl)dibenz[b,f][1,4]oxazepine
Dibenz[b,f][1,4]oxazepine, 11-(4-methyl-1-piperazinyl)-2-(methylsulfonyl)-
DYL8GY448Y
SCHEMBL7407466
DTXSID00176436
Dibenz(b,f)(1,4)oxazepine, 11-(4-methyl-1-piperazinyl)-2-(methylsulfonyl)
Dibenz(b,f)(1,4)oxazepine,11-(4-methyl-1-piperazinyl)-2-(methylsulfonyl)