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Olanzapine

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Identification
Molecular formula
C17H20N4O6
CAS number
132539-06-1
IUPAC name
6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine
State
State

In its usual form, Olanzapine is found as a solid powder at room temperature.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
335.50
Boiling point (Kelvin)
608.65
General information
Molecular weight
312.44g/mol
Molar mass
312.4440g/mol
Density
1.4020g/cm3
Appearence

Olanzapine crystals appear as a yellowish powder. It is commonly used in its solid form, which may be further processed into tablets for pharmaceutical applications.

Comment on solubility

Solubility of 6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine

The solubility of 6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine is an important aspect to consider in various applications, particularly in pharmaceutical formulations. This compound's solubility characteristics can be influenced by several factors, including:

  • Polarity: The presence of polar functional groups may enhance solubility in polar solvents, while nonpolar characteristics could favor solubility in organic solvents.
  • pH Levels: Changes in pH can significantly affect the ionization of certain moieties, leading to alterations in solubility.
  • Temperature: Generally, increasing the temperature may increase solubility for many organic compounds, though this is not universal.
  • Particle Size: Smaller particle sizes can increase surface area, potentially enhancing dissolution rates and solubility.

It is also noteworthy that many complex organic compounds, including this one, often exhibit limited solubility in water, typically necessitating the use of solvents such as:

  • DMSO (Dimethyl sulfoxide)
  • Acetonitrile
  • Dimethylformamide (DMF)

As a general observation, compounds similar to 6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine often possess moderate to low water solubility, which can be a challenge during drug development and might necessitate formulation strategies such as:

  • Co-solvent systems
  • Use of solubilizing agents
  • Nanoparticle technology

Understanding the solubility of this compound will play a crucial role in determining its bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about 6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine

6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine is a fascinating compound with intriguing applications and properties that make it an interesting subject for research and study. Here are some notable points:

  • Pharmaceutical Relevance: This compound belongs to a class of compounds that have shown promise in medicinal chemistry, particularly in the development of antipsychotic agents. Its unique structure provides a platform for exploring how structural modifications can influence pharmacological activity.
  • Complex Structure: The multi-ring system in its structure is characteristic of many bioactive compounds, which allows for potential interactions with various biological targets. The presence of a nitro group, for example, can enhance the compound's reactivity and biological efficacy.
  • Potential Research Avenues: Scientists are continually investigating how modifications to the piperazine moiety can yield compounds with improved selectivity and reduced side effects, which could lead to more effective treatments for mental health disorders.
  • Mechanism of Action: While the specific mechanisms for this compound still require extensive study, it is hypothesized that it may interact with dopaminergic and serotonergic receptors, two key systems in the brain that regulate mood and behavior.

In summary, 6-(4-methylpiperazin-1-yl)-8-nitro-benzo[b][1,4]benzoxazepine serves as a compelling example of how small changes in molecular structure can lead to significant differences in pharmacological effects. As research continues, the understanding of this compound's role in the field of medicinal chemistry will undoubtedly evolve, making it a compound worth watching!

Synonyms
BRN 0582289
DIBENZ(b,f)(1,4)OXAZEPINE, 11-(4-METHYL-1-PIPERAZINYL)-2-NITRO-
DTXSID70176029
11-(4-Methylpiperazino)-2-nitrodibenzoxazepine
21636-37-3
11-(4-Methyl-1-piperazinyl)-2-nitrodibenz(b,f)(1,4)oxazepine
RefChem:337013
DTXCID8098520
SCHEMBL142365