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Niflumic acid

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Identification
Molecular formula
C13H9F3NO2
CAS number
4394-00-7
IUPAC name
6-[4-(trifluoromethyl)phenyl]morpholin-3-one
State
State

At room temperature, Niflumic acid is typically a solid.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
253.30
Boiling point (Kelvin)
526.45
General information
Molecular weight
282.68g/mol
Molar mass
282.6770g/mol
Density
1.5820g/cm3
Appearence

Niflumic acid appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 6-[4-(trifluoromethyl)phenyl]morpholin-3-one

The solubility of 6-[4-(trifluoromethyl)phenyl]morpholin-3-one is influenced by several factors, particularly due to the presence of the trifluoromethyl group, which can impart unique properties to the compound. Understanding its solubility can be essential for various applications. Here are some key points to consider:

  • Polar and Non-polar Balance: The morpholine ring is generally polar, while the trifluoromethyl group is relatively non-polar. This combination can lead to properties that might result in moderate solubility in polar solvents and limited solubility in non-polar solvents.
  • Solvent Choice: The compound is likely more soluble in:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Water – to some extent, but significantly less due to its hydrophobic characteristics.
  • Temperature Influence: As with many compounds, solubility can increase with temperature; thus, heating the solvent might enhance the dissolution rate of 6-[4-(trifluoromethyl)phenyl]morpholin-3-one.
  • pH Considerations: If the chemical structure allows for ionization, variations in pH could also affect solubility, possibly enhancing it under certain conditions.

In summary, while 6-[4-(trifluoromethyl)phenyl]morpholin-3-one exhibits solvent-specific solubility characteristics, it embodies a unique blend that may require systematic experimental approaches to fully understand its behavior in different environments. As with many organic compounds, context is crucial!

Interesting facts

Interesting Facts about 6-[4-(Trifluoromethyl)phenyl]morpholin-3-one

6-[4-(Trifluoromethyl)phenyl]morpholin-3-one is a remarkable compound with unique properties and uses. Here are some noteworthy facts:

  • Structural Diversity: The compound features a morpholine ring, which is known for its five-membered cyclic structure containing both nitrogen and oxygen atoms. This is significant in the fields of medicinal chemistry and material science.
  • Fluorination Effects: The presence of the trifluoromethyl group (–CF3) enhances the lipophilicity and metabolic stability of the compound. This can lead to improved bioavailability in pharmaceutical applications.
  • Biological Relevance: Compounds containing morpholine can exhibit a wide range of biological activities, including analgesic, antibacterial, and antifungal properties. The trifluoromethyl substitution may contribute to its efficacy in drug design.
  • Synthetic Applications: This compound could serve as an intermediate in the synthesis of more complex chemicals, particularly in the development of agrochemicals and pharmaceuticals.
  • Research Potential: With ongoing research into fluorinated compounds, 6-[4-(trifluoromethyl)phenyl]morpholin-3-one may reveal new pathways for innovation in drug discovery and development.

In summary, the unique structure of 6-[4-(trifluoromethyl)phenyl]morpholin-3-one opens doors for its exploration in various fields, combining the intriguing characteristics of morpholines and the benefits of fluorination. As research continues, the compound's potential applications could significantly impact medicinal and industrial chemistry.

Synonyms
FLUMETRAMIDE
7125-73-7
6-(4-(Trifluoromethyl)phenyl)morpholin-3-one
6-[4-(trifluoromethyl)phenyl]morpholin-3-one
Duraflex
MCN-1546
3-Morpholinone, 6-[4-(trifluoromethyl)phenyl]-
604P380W06
3-Morpholinone, 6-(4-(trifluoromethyl)phenyl)-
6-(alpha,alpha,alpha-Trifluoro-p-tolyl)-3-morpholinone
Flumetramide [USAN:INN]
Flumetramida
UNII-604P380W06
Duraflex (TN)
FLUMETRAMIDE [MI]
Flumetramide (USAN/INN)
FLUMETRAMIDE [INN]
FLUMETRAMIDE [USAN]
SCHEMBL258835
CHEMBL2105520
DTXSID40864007
UODXSCCNACAPCE-UHFFFAOYSA-N
NS00003562
D04209
Q27263161
6-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-3-MORPHOLINONE