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Edoxaban

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Identification
Molecular formula
C24H30N6O4S
CAS number
480449-70-5
IUPAC name
6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one
State
State

At room temperature, Edoxaban exists in a solid state, usually in the form of crystalline powder. It is stable at room conditions and maintains its structure unless exposed to extreme conditions.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
548.05g/mol
Molar mass
548.0540g/mol
Density
1.3436g/cm3
Appearence

Edoxaban appears as a crystalline solid. It typically forms white or almost white crystals, indicating its purity and level of refinement. The appearance might slightly vary based on its form and any present impurities.

Comment on solubility

Solubility of 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one

The solubility of 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one can be an intriguing subject due to its unique structure and functional groups. Understanding its solubility characteristics is vital for applications in drug formulation and biochemistry.

Generally, the solubility of a compound like this is influenced by several factors:

  • Polarity: The presence of polar functional groups, such as amino and carbonyl groups, may enhance solubility in polar solvents like water.
  • Hydrogen bonding: The ability of the compound to form hydrogen bonds with solvent molecules can significantly boost solubility.
  • Molecular size: Larger molecular structures tend to exhibit lower solubility due to steric hindrance.
  • Solvent interactions: Compatibility with various solvents plays a crucial role—this compound might be more soluble in organic solvents due to its aromatic characteristics.

Despite these factors, determining the exact solubility might require empirical measurements. As stated, "solubility is not just a static property but a dynamic interaction between the solute and solvent." Hence, experimental dissolution tests are often necessary for precise data.
In conclusion, while the theoretical considerations provide a basis, practical solubility may vary widely based on environmental conditions and preparation methods.

Interesting facts

6-Amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one

This intriguing compound belongs to a class of chemicals known as chromenes, characterized by their unique structure which includes a chromone core. Chromenes and their derivatives have gained substantial attention in medicinal chemistry due to their diverse biological activities.

Biological Significance

One of the notable aspects of 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one is its potential pharmacological applications. Here are a few key points regarding its importance in the field of medicine:

  • Antioxidant Properties: Compounds like this one often exhibit significant antioxidant activities, which are crucial in combating oxidative stress in biological systems.
  • Anti-inflammatory Effects: Research has shown that chromene derivatives may be involved in reducing inflammation, a common factor in many chronic diseases.
  • Neuroprotective Actions: Due to its structure, this compound may have implications for neuroprotection, making it a candidate for treating neurodegenerative disorders.

Structural Insights

The structure of 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one features:

  • Amino Group: This functional group can enhance the compound's water solubility and influence its biological activity.
  • Piperidine Ring: The inclusion of a 1-piperidyl group can be pivotal for the compound's interaction with biological targets, potentially increasing its efficacy.
  • Carbonyl Functionality: The presence of the ketone group contributes to the compound's reactivity and compatibility with various biological systems.

Research and Development

In the ongoing quest for novel therapeutic agents, compounds like 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one pave the way for new discoveries. As researchers delve deeper into its mechanisms of action, this compound may reveal more about:

  • Enhanced drug design
  • Synergistic effects with other chemical entities
  • Potential side effects and toxicity profiles

In summary, 6-amino-3-[2-oxo-2-(1-piperidyl)ethyl]chromen-2-one stands out due to its promising medicinal properties and unique structural features. Continued research in this area may catalyze breakthroughs in pharmaceutical applications, showcasing the importance of understanding even the complex structures of chemical compounds.

Synonyms
18144-59-7
COUMARIN, 6-AMINO-3-((PIPERIDINOCARBONYL)METHYL)-
6-Amino-3-((piperidinocarbonyl)methyl)coumarin
BRN 1257974
DTXSID70171155
5-20-03-00448 (Beilstein Handbook Reference)
DTXCID9093646
6-amino-3-(2-oxo-2-piperidin-1-ylethyl)chromen-2-one
6-Amino-3-(2-oxo-2-(piperidin-1-yl)ethyl)-2H-chromen-2-one
6-amino-3-[2-oxo-2-(piperidin-1-yl)ethyl]-2H-chromen-2-one